Copy Number Variation in Domestication

First author: Zoe N. Lye; Affiliations: New York University (纽约大学): New York, USA

Corresponding author: Michael D. Purugganan

Domesticated plants have long served as excellent models for studying evolution. Many genes and mutations underlying important domestication traits have been identified, and most causal mutations appear to be SNPs. Copy number variation (CNV) is an important source of genetic variation that has been largely neglected in studies of domestication. Ongoing work demonstrates the importance of CNVs as a source of genetic variation during domestication, and during the diversification of domesticated taxa. Here, we review how CNVs contribute to evolutionary processes underlying domestication, and review examples of domestication traits caused by CNVs. We draw from examples in plant species, but also highlight cases in animal systems that could illuminate the roles of CNVs in the domestication process.

驯化的植物是研究演化的绝佳模式物种。许多重要驯化性状相关的基因和突变已经被鉴定出来，且大多数关键突变都是一些SNP。拷贝数变异是一类重要的遗传变异来源，在以往的研究中很大程度上被忽视了。一些正在进行的研究显示拷贝数变异是驯化和驯化物种多样化过程中重要的遗传变异来源。本文，作者总结了在驯化过程中，拷贝数变异是如何作用于演化进程的，并且列举了一些由拷贝数变异所导致的驯化性状的例子。作者在本文中主要从植物物种出发，但也指明了动物系统中的一些案例有助于理解驯化过程中拷贝数变异的作用。

通讯：Michael Purugganan (http://as.nyu.edu/content/nyu-as/as/faculty/michael-purugganan.html)

个人简介：1985年，菲律宾大学，化学学士；1986年，哥伦比亚大学，化学硕士；1993年，佐治亚大学，植物学博士。

研究方向：植物适应的演化和生态基因组学研究；植物驯化的遗传学研究；多细胞和社会性行为的演化。

doi: https://doi.org/10.1016/j.tplants.2019.01.003

Journal: Trends in Plant Science

Published online: February 08, 2019