SUPPRESSOR OF GAMMA RESPONSE 1 links DNA damage response to organ regeneration

Corresponding author: Anne B Britt

In Arabidopsis, DNA damage-induced programmed cell death is limited to the meristematic (分生组织的) stem cell niche (干细胞龛) and its early descendants (后代). The significance of this cell-type specific programmed cell death is unclear. Here we demonstrate in roots that it is the programmed destruction of the mitotically-compromised stem cell niche that triggers its regeneration, enabling growth recovery. In contrast to wild-type plants, sog1 plants, which are defective in damage-induced programmed cell death, maintain the cell identities and stereotypical (典型的) structure of the stem cell niche after irradiation, but these cells fail to undergo cell division, terminating (终止) root growth. We propose DNA damage-induced programmed cell death is employed by plants as a developmental response, contrasting with its role as an anti-carcinogenic response (抗致癌反应) in animals. This role in plants may have evolved to restore (恢复) the growth of embryos after the accumulation of DNA damage in seeds.

在拟南芥中，DNA损伤所诱导的细胞程序性死亡在分生组织的干细胞龛及其早期分裂出的子细胞中是受到限制的。关于这种细胞类型特异性细胞程序性死亡的特性还处于未知状态。本文揭示了在拟南芥的根中，干细胞龛的编程性死亡会诱导其再生，使得生长恢复。与野生型相反，在损伤诱导的细胞程序性死亡上有所缺陷的sog1突变体在辐射处理后会保持细胞特性和干细胞龛的典型结构，当这些细胞会不能进行细胞分裂，因此根的生长被终止。作者认为DNA损伤所诱导的细胞程序性死亡在植物中起到一个发育响应的功能，这与动物中所表现的抗致癌响应是相反的。植物中的这个特性可能是为了在种子中DNA损伤积累后恢复胚的生长。

通讯：Anne B Britt (http://biosci3.ucdavis.edu/faculty/profile/view/192)

个人简介：1981年，麻省理工学院，生物学士；1986年，加利福尼亚大学伯克利分校，生物化学博士。

doi: https://doi.org/10.1104/pp.17.01274