文章：Low diversity of the gut microbiota in infants with atopiceczema

时间：2011

研究目的：We have used barcoded16S rRNA 454-pyrosequencing to assess the microbial diversity and characterize the dominant bacteria in stool during the first year of life in infants who either had atopic eczema or did nothave any allergic manifestation up to 2 years of age.

研究样本：In this study the infants received probiotics or placebo daily from day 1 to 3 until 12 months of age.

研究结果：

1) Infants with IgE-associated eczema had a lower diversity of the total microbiota at 1 month (P =.004) and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P =.02 and P =.01) and the phylum Proteobacteria at 12 months of age (P 5 .02).

2) The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability.

3) At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in infants without allergic manifestation.