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Andrew fire, an American scientist and biomedical scientist, was born in 1959 in the United States. In 1983, he received his Ph.D. in biology from the Massachusetts Institute of technology. In 1998, he and Craig Mello, Professor of the University of Massachusetts School of medicine, published a paper in the journal Nature, saying that they had discovered that RNA could interfere with genes. They won the 2006 Nobel Prize in physiology or medicine together for their outstanding contributions to RNA (ribonucleic acid) interference mechanism. Andrew Farr is Professor of pathology and genetics at Stanford medical school.
安德鲁·法尔(AndrewFire),美国科学家、生物医学家,1959年出生于美国,美国科学家、生物医学家。1983年获美国麻省理工学院生物学博士学位。1998年,他和美国马萨诸塞大学医学院教授克雷格·梅洛在《自然》杂志上共同发表论文,称他们发现了RNA具有可以干扰基因的机制。因在RNA(核糖核酸)干扰机制方面的突出贡献,他俩一起获得了2006年度诺贝尔生理学或医学奖。安德鲁·法尔现任斯坦福医学院病理学和遗传学教授。
https://pubmed.ncbi.nlm.nih.gov/?term=Fire+AZ&cauthor_id=18007671
https://pubmed.ncbi.nlm.nih.gov/18007671/
https://pubmed.ncbi.nlm.nih.gov/17722137/
http://www.pubmedplus.cn/P/SearchQuickResult?wd=3bc30ae1-e6ad-43c4-854e-69fabd0be7d0
Cell Death Differ
. 2007 Dec;14(12):1998-2012.
doi: 10.1038/sj.cdd.4402253.
PMID: 18007671
Thanks to the Nobel Foundation for permission to publish this Lecture. We report here the Nobel Lecture delivered by Professor Andrew Z Fire. Together with the accompanying lecture by Professor Mello this lecture describes the exciting years leading to the discovery of RNA interference (RNAi) and some of the underlying molecular mechanisms. Professor Fire nicely points out his own contribution and the contribution of other research groups to the development of this field. He also presents an interesting discussion on the role of RNAi in immunity and challenges us with a number of open questions. The lecture ends presenting the great potential of exploiting RNAi for therapeutical purposes.
Return to the RNAi world: rethinking gene expression and evolution.
Cell Death Differ. 2007 Dec;14(12):2013-20. doi: 10.1038/sj.cdd.4402252.PMID: 18007672
RNA interference: big applause for silencing in Stockholm.
Cell. 2006 Dec 15;127(6):1083-6. doi: 10.1016/j.cell.2006.12.001.PMID: 17174883
Methods Mol Biol. 2004;254:35-48. doi: 10.1385/1-59259-741-6:035.PMID: 15041754 No abstract available.
Biology and Mechanisms of Short RNAs in Caenorhabditis elegans.
Adv Genet. 2013;83:1-69. doi: 10.1016/B978-0-12-407675-4.00001-8.PMID: 23890211 Review.
RNA interference (RNAi) patents and human health related applications of RNAi.
Recent Pat DNA Gene Seq. 2007;1(2):128-33. doi: 10.2174/187221507780887036.PMID: 19075926 Review.
Front Microbiol. 2021 Jul 9;12:660976. doi: 10.3389/fmicb.2021.660976. eCollection 2021.PMID: 34305830 Free PMC article.
Transgenic Res. 2021 Apr;30(2):129-141. doi: 10.1007/s11248-020-00232-9. Epub 2021 Feb 20.PMID: 33609253 Review.
Sci Rep. 2020 Nov 9;10(1):19367. doi: 10.1038/s41598-020-76423-5.PMID: 33168938 Free PMC article.
Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring.
Biomed Res Int. 2020 Mar 31;2020:4525410. doi: 10.1155/2020/4525410. eCollection 2020.PMID: 32337248 Free PMC article. Review.
Innovative approaches for cancer treatment: current perspectives and new challenges.
Ecancermedicalscience. 2019;13:961. doi: 10.3332/ecancer.2019.961.PMID: 31537986 Free PMC article.
Animals
Caenorhabditis elegans / genetics
Gene Silencing*
Immunity
Models, Biological
RNA Interference
RNA, Double-Stranded / metabolism*
Angew Chem Int Ed Engl
. 2007;46(37):6966-84.
doi: 10.1002/anie.200701979.
Affiliations expand
PMID: 17722137
No abstract available
Plants, RNAi, and the Nobel Prize.
Science. 2006 Nov 24;314(5803):1242-3.PMID: 17128501 No abstract available.
Exploring the uses of RNAi--gene knockdown and the Nobel Prize.
N Engl J Med. 2006 Dec 7;355(23):2391-3. doi: 10.1056/NEJMp068242.PMID: 17151363 No abstract available.
[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference].
Ned Tijdschr Geneeskd. 2006 Dec 30;150(52):2849-53.PMID: 17319214 Dutch.
[RNAi-RNA interference--an efficient way for silence].
Postepy Biochem. 2003;49(3):136-46.PMID: 15083606 Review. Polish. No abstract available.
Post-transcriptional gene silencing by double-stranded RNA.
Nat Rev Genet. 2001 Feb;2(2):110-9. doi: 10.1038/35052556.PMID: 11253050 Review.
Sci Rep. 2022 Feb 8;12(1):2141. doi: 10.1038/s41598-022-06193-9.PMID: 35136178 Free PMC article.
Genetics. 2022 Jan 4;220(1):iyab170. doi: 10.1093/genetics/iyab170.PMID: 34791196
Genes (Basel). 2020 Oct 26;11(11):1258. doi: 10.3390/genes11111258.PMID: 33114530 Free PMC article.
World Allergy Organ J. 2020 Aug 11;13(8):100447. doi: 10.1016/j.waojou.2020.100447. eCollection 2020 Aug.PMID: 32817781 Free PMC article.
Crit Rev Toxicol. 2019 May;49(5):411-429. doi: 10.1080/10408444.2019.1626801. Epub 2019 Jul 3.PMID: 31268799 Free PMC article. Review.
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