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Two years ago, a researcher who worked in the same area in the Cummings Life Science Center, geneticist Malcolm Casadaban, a co-principal investigator with Schneewind, died after becoming infected with a weakened strain of the Yersinia pestis bacterium that was not thought to infect healthy adults. According to a report in the Centers for Disease Control and Prevention's Mortality and Morbidity Weekly Report, Casadaban may have become sick because he had hemochromatosis, or an overload of iron in the body. The Y. pestis strain had been weakened by making it less able to acquire iron, and the excess iron in Casadaban's body might have allowed it to be become more virulent, the MMWR report says.
Neither case involved a select agent—a pathogen on CDC's list of potential agents in a biological attack. (Although Y. pestis is on the list, the strain Casadaban studied was excluded.) But Schneewind also directs the Great Lakes Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, a consortium funded by the National Institute of Allergy and Infectious Diseases (NIAID) to study select agents and natural threats. The center does some of its work at a major biosafety level-3 lab on the campus of Argonne National Laboratory, one of a dozen such regional biocontainment labs built partly with NIAID funding after the 2001 anthrax attacks.
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