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塞拉利尼论文再版感言:科学自己说明一切(中英对照)

已有 5925 次阅读 2014-6-26 16:30 |个人分类:环保呐喊|系统分类:海外观察| 转基因, 论文, 科学态度, 塞拉利尼, 长期实验

【明辨是非】 科学是什么?是事实,是证据,不是什么推理,诬陷,造谣,游说,收买,打击报复。声称转基因技术安全的专家,为什么自己就不能做一个实验来看看呢?既然说安全,数据呢?是怎样设计的实验呢?如果都没有,现在补做也是来得及的。用静止的观点,用孤立的观点来理论推测异常复杂的生命现象,有时是会闹笑话的,是要付出代价的。不论是学问有多大的科学家,都要懂得谦虚谨慎这个基本道理啊!急赤白脸地宣布那玩意儿安全无害,比喝凉水还安全,比食盐还安全,猪吃90天没事人吃也没事,这是科学的态度吗?转基因争论这么多年,对方给我的印象是,在资本主导的科学研究方面,科学回到了中世纪的黑暗——容不得质疑,一质疑就跳,一跳就打压。人类需要再次发起对资本主导的“科学”教的文艺复兴运动了。欣喜的是,正能量在全球开始回归,中华有救矣!人类有救了!在这场新的“启蒙”运动中,法兰西人,好样的。


法国科学家塞拉利尼论文再次出版:科学自己说明一切

转载、翻译、评论者:陈一文(cheniwan@cei.gov.cn

转载自:

http://www.gmoseralini.org/republication-seralini-study-science-speaks/

 

Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize

重新发表的研究:草甘膦除草剂农达与抗草甘膦转基因玉米的长期毒性

 

作者:Gilles-Eric Séralini1*, Emilie Clair1, Robin Mesnage1, Steeve Gress1, Nicolas Defarge1, Manuela Malatesta2, Didier Hennequin3 and Joël Spiroux de Vendômois1

 

作者单位:

a University of Caen, Institute of Biology, CRIIGEN and Risk Pole, MRSH-CNRS, EA 2608, Esplanade de la Paix, Caen Cedex 14032, France

a、法国卡昂大学,生物研究所,

b University of Verona, Department of Neurological, Neuropsychological, Morphological

b、维罗纳大学,神经学、神经心理学、形态系

 

Abstract

摘要

 

Background: The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the diet), cultivated with or without Roundup application and Roundup alone (from 0.1 ppb of the full pesticide containing glyphosate and adjuvants) in drinking water, were evaluated for 2 years in rats. This study constitutes a follow-up investigation of a 90-day feeding study conducted by Monsanto in order to obtain commercial release of this GMO, employing the same rat strain and analyzing biochemical parameters on the same number of animals per group as our investigation. Our research represents the first chronic study on these substances, in which all observations including tumors are reported chronologically. Thus, it was not designed as a carcinogenicity study. We report the major findings with 34 organs observed and 56 parameters analyzed at 11 time points for most organs. Results:Biochemical analyses confirmed very significant chronic kidney deficiencies, for all treatments and both sexes; 76% of the altered parameters were kidney-related. In treated males, liver congestions and necrosis were 2.5 to 5.5 times higher. Marked and severe nephropathies were also generally 1.3 to 2.3 times greater. In females, all treatment groups showed a two- to three fold increase in mortality, and deaths were earlier. This difference was also evident in three male groups fed with GM maize. All results were hormone- and sex-dependent, and the pathological profiles were comparable. Females developed large mammary tumors more frequently and before controls; the pituitary was the second most disabled organ; the sex hormonal balance was modified by consumption of GM maize and Roundup treatments. Males presented up to four times more large palpable tumors starting 600 days earlier than in the control group, in which only one tumor was noted. These results may be explained by not only the non-linear endocrine disrupting effects of Roundup but also by the over expression of the EPSPS transgene or other mutational effects in the GM maize and their metabolic consequences. Conclusion: Our findings imply that long-term (2 year) feeding trials need to be conducted to thoroughly evaluate the safety of GM foods and pesticides in their full commercial formulations.

背景:对抗草甘膦除草剂转基因玉米(饮食中11%与更多)、种植时喷洒或者不喷洒草甘膦除草剂,以及仅饮水含草甘膦除草剂农达完整成分(含草甘膦及其辅佐剂的草甘膦除草剂农达0.ppb),对老鼠健康的影响,进行了两年试验。该项研究构成孟山都未获得这种转基因玉米商业化释放进行的喂养90天研究的跟踪调查,我们的研究使用了对孟山都同种老鼠品种、每组同量动物数量,对它们分析了各种生物化学指标。我们的研究代表对于这些物质的头一项慢性研究,对观察中发现包括肿瘤在内的情况进行了时间顺序性报告。因而该项试验原本并没有作为致癌性毒理学研究。我们报过了对于所观察的34种器官的主要发现,对大部分器官在11个时间点观察了56个指标。结果:生物化学分析确认非常显著的肾慢性不足,对所有处理组雌雄皆如此;发生改变的指标中76%与肾脏相关。在雄性处理组中,肝淤血与和坏死比对照组高2.55.5倍。在雌鼠中,所有的处理组显示死亡率通常高1.32.3倍,而且死亡的更早。这种差别在喂养转基因玉米的三组雄鼠组中也明显。所有的结果都激素与性别依赖,而且病理资料具有可比性。雌鼠比对照组发育更大更高频率的乳房肿瘤,而且发育的更早;垂体是第二个最出现功能丧失的器官;喂养转基因玉米与农达除草剂改变了性激素平衡。雄鼠处理组比对照组产生4倍多的明显大肿瘤,而且比对照组早600天发生,对照组中仅观察到一个肿瘤。这些结果可能不能仅仅由农达的非线性内分泌干扰作用予以解释,还可以由EPSPS转基因过量表达或其他突变效应在转基因玉米及其代谢的后果予以解释。结论:我们的发现意味着必须进行长期(2年)喂养试验才能充分评估转基因食品及其完整商业性配方农药残留的安全性。

 

Keywords: Genetically modified; GMO; Roundup; NK603; Rat; Glyphosate-based herbicides; Endocrine disruption

关键词:基因修饰 转基因生物体 NK603 老鼠 草甘膦为基础除草剂 内分泌干扰

 

Republished journal: Environmental Sciences Europe 2014, 26:14

重新发表该项研究的学术刊物:欧洲环境科学20142614

 

The electronic version of this article online at:

该篇文章完整电子版在线提供:

http://www.enveurope.com/content/26/1/14

 

Received:  22 March 2014

收到日期:2014322

 

Accepted:  16 May 2014

接受日期:2014516

 

Published: 24 June 2014

发表日期:2014624

 

© 2014 Séralini et al.; licensee Springer 

© 2014 Séralini et al.;被许可人Springer 出版公司


GMOSeralini.org welcomes the news of the republication of the chronic toxicity study on the glyphosate-based herbicide Roundup and a commercialized genetically modified (GM) maize, Monsanto’s NK603, led by Prof Gilles-Eric Séralini.

       GMOSeralini.org网站(=转基因塞拉利尼网站)欢迎这个消息:G-E·塞拉利尼教授领衔对商业性转基因玉米NK 603进行的慢性毒性研究论文再次出版。

The republication restores the study to the peer-reviewed literature so that it can be consulted and built upon by other scientists.

   再次出版将该项研究重新存储到经同行专家审查的文献,使其他科学家可以引证到自己的论述中。 

The study found severe liver and kidney damage and hormonal disturbances in rats fed the GM maize and low levels of Roundup that are below those permitted in drinking water in the EU. Toxic effects were found from the GM maize tested alone, as well as from Roundup tested alone and together with the maize. Additional unexpected findings were higher rates of large tumours and mortality in most treatment groups.

   该项研究在喂养转基因玉米与地域欧盟饮用水允许微量水平的草甘膦除草剂农达的老鼠中发现严重的肝脏与肾脏损伤以及激素干扰。单独喂养转基因玉米(种植过程不喷洒草甘膦除草剂因而不含草甘膦残留的转基因玉米--译注)的老鼠、仅喂食低微量草甘膦除草剂农达的老鼠,以及喂养含草甘膦残留的转基因玉米(种植过程喷洒草甘膦除草剂因而含草甘膦残留的转基因玉米--译注)的老鼠,都发现了毒性作用。除此之外,在大部分处理组中,还发现了未曾预料的高比例大肿瘤与死亡 

The study was first published in Food and Chemical Toxicology (FCT) in September 2012[1] but was retracted by the editor-in-chief in November 2013 after a sustained campaign of criticism and defamation by pro-GMO scientists.[2]

   该项研究20129月首先发表在《食品与化学毒理学》(FCT[1],但是在力挺转基因的一批科学家发动的持续抨击与诽谤运动后201311月遭刊物总编撤稿。[2] 

Now the study has been republished by Environmental Sciences Europe. The republished version contains extra material addressing criticisms of the original publication. The raw data underlying the study’s findings are also published – unlike the raw data for the industry studies that underlie regulatory approvals of Roundup, which are kept secret. However, the new paper presents the same results as before and the conclusions are unchanged.

   现在,该项研究由《欧洲环境科学》再次出版。再版的论文包含一些额外的资料来对付对初版论文的批评。作为该项研究基础的原始数据也发表出来--不像产业界为草甘膦除草剂农达获得监管机构批准的试验资料一直保密拒绝公布。然而,再版的新论文提出的结果与以前相同,论文结论也没有改变。 

The republished study is accompanied by a separate commentary by Prof Séralini’s team describing the lobbying efforts of GMO crop supporters to force the editor of FCT to retract the original publication.

   研究论文重新发表时,还一起发表塞拉利尼教授团队的一篇评论文章,描述转基因作物支持者的游说努力迫使《食品化学毒理学》杂志总编撤除该篇论文的情况。 

GMOSeralini.org editor Claire Robinson commented: “This study has now successfully passed no less than three rounds of rigorous peer review.

      GMOSeralini.org网站编辑克莱尔·罗宾森评论:该项研究目前成功通过了不少于三轮严格的同行专家审查。 

“The first was for the initial publication of the study in Food and Chemical Toxicology. It passed with only minor revisions, according to the authors.[3]

   “首次在《食品与化学毒理学》上发表时,它通过了同行审查,只做了很少的修改,论文作者说。[3] 

“The second review took months. It involved a non-transparent examination of Prof Séralini’s raw data by a secret panel of unnamed persons organized by the editor-in-chief of FCT, A. Wallace Hayes, in response to criticisms of the study by pro-GMO scientists.[4,5]

   “第二次审查花费了数个月。它涉及由《食品与化学毒理学》总编A. Wallace Hayes组织的由匿名人士组成的秘密专家组对塞拉利尼教授的原始数据进行不透明审查,以应对挺转基因科学家的抨击[45] 

“In a letter to Prof Séralini, Hayes admitted that the anonymous reviewers found nothing ‘incorrect’ about the results presented. However, Hayes pointed to what he said was the ‘inconclusive’ nature of some aspects of the paper, namely the tumour and mortality observations, to justify his decision to retract the study.[6]

   “在致塞拉利尼教授的一封信中,《食品与化学毒理学》总编Hayes承认匿名审查者没有发现研究论文提交的结果有任何不正确之处然而,Hayes仅指出他称之为这篇论文某些方面,即对于肿瘤与死亡率的观察,的不确定性”性质,作为他决定撤除这篇论文的理由。[6] 

“The rationale given for the retraction was widely criticized by scientists as an act of censorship and a bow to the interests of the GMO industry.[7,8] Some scientists pointed out that numerous published scientific papers contain inconclusive findings, including Monsanto’s own short (90-day) study on the same GM maize, and have not been retracted.[9] The retraction was even condemned by a former member of the editorial board of FCT.[10]

   “对撤除论文给出的理由遭到科学家们广泛的批评,认为是屈服于转基因生物产业的利益的审查制度。[78]某些科学家指出众多发布了的科学论文含有不确定性的发现,包括孟山都自己对转基因玉米进行的短期(90天)研究论文,而没有因此遭到撤稿。[9]撤除塞拉利尼教授论文甚至遭到《食品与化学毒理学》杂志编辑部前任成员的谴责。[10]、 

“Now the study has passed a third peer review arranged by the journal that is republishing the study, Environmental Sciences Europe.[11]

   “现在,该项研究论文通过了重新发表这篇论文的学术刊物《欧洲环境科学》杂志组织的第三轮同行专家审查。[11] 

Comments from scientists

   科学家的评论 

Dr Michael Antoniou, a molecular geneticist based in London, commented, “Few studies would survive such intensive scrutiny by fellow scientists. The republication of the study after three expert reviews is a testament to its rigour, as well as to the integrity of the researchers.

   迈克尔·安托尼博士,在伦敦工作的一位分子基因学家,评论,“很少的研究能够通过同行科学家如此严格审查。经过三轮转基因审查后再次出版这篇论文,证明了其严谨性,以及研究者工作的完整性。 

“If anyone still doubts the quality of this study, they should simply read the republished paper. The science speaks for itself.

   “如果还有人质疑这篇研究论文的质量,他们应当阅读重新发表的这篇论文。科学自我解释一切。 

“If even then they refuse to accept the results, they should launch their own research study on these two toxic products that have now been in the human food and animal feed chain for many years.”

   “阅读了重新发表的这篇论文后如果他们依然拒绝接受该项研究的结果,他们应当对于多年来在人类食品与动物饲料供应中存在的这两种毒性产品(草甘膦除草剂农达与转基因作物--译注)进行自己的试验研究。” 

Dr Jack A Heinemann, Professor of Molecular Biology and Genetics, University of Canterbury New Zealand, called the republication “an important demonstration of the resilience of the scientific community”. Dr Heinemann continued, “The first publication of these results revealed some of the viciousness that can be unleashed on researchers presenting uncomfortable findings. I applaud Environmental Sciences Europe for submitting the work to yet another round of rigorous blind peer review and then bravely standing by the process and the recommendations of its reviewers, especially after witnessing the events surrounding the first publication.

   杰克·A·海尼曼博士,新西兰大学堪培拉大学分子生物学与遗传性教授,称该研究论文的重新发表“科学界韧性的重要演示”。海尼曼博士继续说,“第一次发表这些结果显示出研究人员提出某些不舒服结果时可能披露某些邪恶情况。我赞赏《欧洲环境科学》经过又一轮严格的匿名同行评审后再次提交这篇研究论文,然后勇敢的坚持科学的程序与审查们推荐的意见,特别在见证了首次发表后发生的一系列事件后这样做。 

“This study has arguably prevailed through the most comprehensive and independent review process to which any scientific study on GMOs has ever been subjected.

   “这项研究可以说通过了对转基因生物进行的任何科学研究未曾经历的最全面的和独立的审查过程 

“The work provides important new knowledge that must be taken into account by the community that evaluates and reports upon the risks of genetically modified organisms, indeed upon all sources of pesticide in our food and feed chains. In time these findings must be verified by repetition or challenged by superior experimentation. In my view, nothing constructive for risk assessment or promotion of GM biotechnology has been achieved by attempting to expunge these data from the public record.”

   “该项工作提供了重要的新知识,评估和报告转基因生物风险的科学界必须考虑这些知识,因为我们的食品与饲料供应链中存在着所有来源的农药。这些发现必须不断重复验证,或受到更优越的实验的挑战。以我来看,企图从公共记录中删除这些资料,对转基因生物技术的风险评估或其推动没有任何建设性。”




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