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作者：小丫  来源： 嘉因

今天读review，又看见这个图

Figure 1 Evolving views on the Waddington landscape 

出自Stricker, S.H., Köferle, A. and Beck, S., 2017. From profiles to function in epigenomics. Nature Reviews Genetics, 18(1), p.51.

右图是动画版，这个动画片一点都不好看，就是几个球在滚动，但是它代表的意义重大。

https://mp.weixin.qq.com/s/AKLwnmeEVupno8nMWuxajQ

常来嘉因的小伙伴儿一定也觉得这个点点图似曾相识，因为它经常出现在大牛review和ppt里。

你一定见过这样的重绘版：

Figure 1. Waddington’s Classical Epigenetic Landscape

In 1957, Conrad Waddington proposed the concept of an epigenetic landscape to represent the process of cellular decision-making during development. At various points in this dynamic visual metaphor, the cell (represented by a ball) can take specific permitted trajectories, leading to different outcomes or cell fates. Figure reprinted from Waddington, 1957. 

出自Goldberg, A.D., Allis, C.D. and Bernstein, E., 2007. Epigenetics: a landscape takes shape. Cell, 128(4), pp.635-638.

Yamanaka也对它情有独钟

Fig. 2. Cell fate changes on Waddington's epigenetic landscape. Adapted, with permission, from Waddington (Waddington, 1957).

出自Takahashi, K. and Yamanaka, S., 2013. Induced pluripotent stem cells in medicine and biology. Development, 140(12), pp.2457-2461.

纪念版

Fig. 1. Waddington’s developmental landscape diagram 

出自discusses Conrad, D.N., 2015. Conrad Waddington and the origin of epigenetics.

其实原版长这个样子：

Figure 5 The complex system of interactions underlying the epigenetic landscape. The pegs on the ground represent genes; the strings leading from them the chemical tendencies which the genes produce. The modeling of the epigenetic landscape, whichslopes down from above one's head towards the distance, is controlled by the pull of these numerous guy-ropes which are ultimately anchored to the genes.

出自Waddington, C. H. (1957). The Strategy of the Genes. London: George Allen & Unwin.

原来这个点点图已经60岁了，出自Conrad Waddington之手，就是这位：

他是谁呢？看介绍：

原来是表观遗传的祖师爷啊！祖师爷亲赐神图，毕业论文里一定要放进去，再打印几份，每天拜一拜！答辩必过！小丫打印了好几份。。。

想要祖师爷手绘原版神图，加微信：epigenomics，想要这几篇经典review的pdf文件也找她。

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