||
本文转载自嘉因微信公众号,已获得授权。查看最新文章,敬请关注嘉因,微信ID:rainbow-genome
作者:小丫 来源: 嘉因
今天读review,又看见这个图
Figure 1 Evolving views on the Waddington landscape
出自Stricker, S.H., Köferle, A. and Beck, S., 2017. From profiles to function in epigenomics. Nature Reviews Genetics, 18(1), p.51.
右图是动画版,这个动画片一点都不好看,就是几个球在滚动,但是它代表的意义重大。
https://mp.weixin.qq.com/s/AKLwnmeEVupno8nMWuxajQ
常来嘉因的小伙伴儿一定也觉得这个点点图似曾相识,因为它经常出现在大牛review和ppt里。
你一定见过这样的重绘版:
Figure 1. Waddington’s Classical Epigenetic Landscape
In 1957, Conrad Waddington proposed the concept of an epigenetic landscape to represent the process of cellular decision-making during development. At various points in this dynamic visual metaphor, the cell (represented by a ball) can take specific permitted trajectories, leading to different outcomes or cell fates. Figure reprinted from Waddington, 1957.
出自Goldberg, A.D., Allis, C.D. and Bernstein, E., 2007. Epigenetics: a landscape takes shape. Cell, 128(4), pp.635-638.
Yamanaka也对它情有独钟