本博主曾评论如下

  2013-1-10 06:40 其实换个思路，变通用途，如新型都市排水系统。便可申报国家技术进步奖，世界领先了。许多重大科研成果，新技术，新药都是主产品未能实现的情况下发现的

近十年我国地铁建设质量低下，隐患较多

http://bbs.sciencenet.cn/blog-760649-646583.html

 

下面是关于"伟哥"的意外发现的故事， 当然“伟哥”在科学网因北大张海霞教授的博文在科学网走火，这不是本文的关心的话题， 本文关注低质量地铁的他用。

首先借鉴wiki关于伟哥的描述：

Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent, research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease). The first clinical trials were conducted in Morriston Hospital in Swansea.^[46] Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections.^[1][47] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the United States Food and Drug Administration on March 27, 1998, becoming the first oral treatment approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year.^[48] It soon became a great success: annual sales of Viagra peaked in 2008 at US$1,934 million.^[49]

The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim that Pfizer disputes.^[50] Their names are on the manufacturing patent application, but the original patent on the synthesis of the drug was filed by Nicholas Terrett and Peter Ellis.

大意是说，伟哥本来用于治疗 紧张和心绞痛，结果在临床应用发现有阴茎勃起的功效， 于是便重打旗号，改治疗勃起障碍，商业效益可观。

有些诺贝尔奖的成果也是意外发现， 请其他博主补充。 但是本博文谈国内建造的低质量地铁的用途改变问题: 改为新型都市地下排水系统。 待考证其它城市如巴黎的排水系统，再对这一新型排水系统给出科学依据。 当然如有科研朋友愿意共同进行研究此课题，欢迎加盟。 本博主确信（目前有些盲目），此发现可以申报国家技术进步奖，世界领先了。一旦被提名并或炸药奖，也是科学网或中国的骄傲。 在此先感谢 廖少明教授了。

 

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