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Nature medicine——四氢大麻酚可以改善老年小鼠的认知功能
Abstract
1.Chronic, low-dose THC treatment restores learning ability in aged mice.
2.Molecular changes in the hippocampus induced by low-dose THC treatment.
3.Epigenetic changes induced by low-dose THC treatment in hippocampal tissue.
4.The effects of low-dose THC treatment in mature animals are blocked by the histone acetyltransferase inhibitor anacardic acid and are absent in mice with deletion of Cb1 in glutamatergic neurons.
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