本文为2017年5月Nature Communications文章，原题目为：

Temporal dynamics of gene expression and histone marks at the Arabidopsis shoot meristem during flowering

植物可以通过位于其生长顶端的多能干细胞，即茎尖分生组织（SAM），在其整个生命过程中产生器官。在开花的时候，拟南芥的SAM会改变命运，开始产生花而不再产生叶子。正确的开花时间部分决定了生殖成功，因此这处于环境和内源信号的调控之下。到目前为止，表观遗传学调控如何促进成花转变还没有分析得很清楚，主要是因为SAM的可获得性差。在这里我们报道了在SAM响应光周期诱导的开花中，染色质修饰H3K4me3和H3K27me3的时空动态变化及其相关的转录变化。为强调组织特异性表观基因组分析的重要性，我们检测到在SAM中富集的染色质状态，在整株幼苗中并不明显。此外，我们的研究结果表明，在诱导开花过程中，翻译的调控可能参与了分生组织功能的调整。

Plants can produce organs throughout their entire life from pluripotent stem cells located at their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of Arabidopsis thaliana switches fate and starts producing flowers instead of leaves. Correct timing of flowering in part determines reproductive success, and is therefore under environmental and endogenous control. How epigenetic regulation contributes to the floral transition has eluded analysis so far, mostly because of the poor accessibility of the SAM. Here we report the temporal dynamics of the chromatin modifications H3K4me3 and H3K27me3 and their correlation with transcriptional changes at the SAM in response to photoperiod-induced flowering. Emphasizing the importance of tissue-specific epigenomic analyses we detect enrichments of chromatin states in the SAM that were not apparent in whole seedlings. Furthermore, our results suggest that regulation of translation might be involved in adjusting meristem function during the induction of flowering.

每日一词

pluripotent

英[plʊə'rɪpətənt]

美[plʊr'rɪpətənt]

adj. 多能（性）的;