Hippo pathway in mammary gland development and breast cancer

Peiguo Shi, Jing Feng and Ceshi Chen

Acta Biochim Biophys Sin 2015 Jan, 47(1): 53–59; doi: 10.1093/abbs/gmu114

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, China

Accumulated evidence suggests that the Hippo signaling pathway plays crucial roles in mammary gland development and breast cancer. Key components of the Hippo pathway regulate breast epithelial cell proliferation, migration, invasion, and stemness. Additionally, the Hippo pathway regulates breast tumor growth, metastasis, and drug resistance. It is expected that the Hippo pathway will provide novel therapeutic targets for breast cancer. This review will discuss and summarize the roles of several core components of the Hippo pathway in mammary gland development and breast cancer.

图例: YAP/TAZ对乳腺癌细胞表型的影响

全文: http://abbs.oxfordjournals.org/content/47/1/53.full 

Go to ABBS Volume 47, Number 1, 2015: a special issue on Hippo signaling