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ABBS: miR-375 is possibly transactivated by ASCL1
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miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells
Huijie Zhao, Lei Zhu, Yujuan Jin, Hongbin Ji , Xiumin Yan, and Xueliang Zhu
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
In this study, we identified five miRNAs highlyexpressed in the small-celllungcancer (SCLC) cell line NCI-H209. Among them, the expression levels of miR-375 were dramatically elevated in all SCLC cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1). Moreover, miR-375 was upregulated and correlated with ASCL1 in the cell lines generated from mouse SCLC-like tumors as well. Dual-luciferase assays further showed that ASCL1 activated the expression of miR-375 by binding to the three E-box elements in the miR-375 promoter. These results imply a role of ASCL1 in SCLC via the upregulation of miR-375.
图例: ASCL1通过启动子的E-box区激活miR-375的表达
Acta Biochim Biophys Sin (Shanghai). 2012 Feb;44(2):177-82. doi: 10.1093/abbs/gmr110
全文: http://abbs.oxfordjournals.org/content/44/2/177.full
引用此文的文献:
4 Upregulation of microRNA-375 is associated with poor prognosis in pediatric acute myeloid leukemia
8 miRNA expression profiles associated with diagnosis and prognosis in lung cancer
9 miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling
https://blog.sciencenet.cn/blog-592748-844303.html
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