Hyperbaric Oxygen Treatment for Long COVID: From Molecular Mechanism to Clinical Practice

作者：Jian-qing Pan, Zhi-min Tian & Lian-bi Xue

Pan, Jq., Tian, Zm. & Xue, Lb. Hyperbaric Oxygen Treatment for Long COVID: From Molecular Mechanism to Clinical Practice. CURR MED SCI 43, 1061–1065 (2023). https://doi.org/10.1007/s11596-023-2799-1

// 文章简介

长新冠最常见的症状包括疲劳、呼吸困难、咳嗽和认知功能障碍，其机制尚未完全明确，但学者们已经提出了一些科学假设，并已经开展了一些使用高压氧疗法治疗长期新冠的临床试验。结果显示，高压氧疗法有助于改善症状严重程度、缩短症状持续时间并提高患者的生活质量。本文作者从分子机制到临床实践对长新冠的高压氧治疗进行了综述介绍。

Long COVID symptoms typically occur within 3 months of an initial COVID-19 infection, last for more than 2 months, and cannot be explained by other diagnoses. The most common symptoms include fatigue, dyspnea, coughing, and cognitive impairment. The mechanisms of long COVID are not fully understood, but several hypotheses have been put forth. These include coagulation and fibrosis pathway activation, inflammatory and autoimmune manifestations, persistent virus presence, and Epstein-Barr virus reactivation. Hyperbaric oxygen therapy (HBOT) is a therapeutic method in which a person inhales 100% oxygen under pressure greater than that of the atmosphere. HBOT has some therapeutic effects, including improvement of microcirculation, inhibition of cytokine release leading to a reduction in inflammatory responses, inhibition of autoimmune responses, and promotion of neurological repair. Several clinical trials have been carried out using HBOT to treat long COVID. The results suggest that HBOT helps to improve symptom severity, reduce symptom duration, and enhance patients’ quality of life. It is believed that HBOT is an effective option for patients with long COVID, which is worth actively promoting.