Medroxyprogesterone acetate 

MCE 国际站：Medroxyprogesterone acetate

中文名：醋酸甲羟孕酮

CAS：71-58-9

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性： Medroxyprogesterone acetate 是一种广泛使用的合成类固醇，因为它与 progesterone、androgen 和 glucocorticoid receptors^[1] 相互作用。

体外：Medroxyprogesterone acetate (10 和 0.5 nM，48 小时) 抑制类固醇剥夺的 HUVEC eNOS 表达[2]。Medroxyprogesterone acetate (10 和 0.5 nM，16 小时) 通过减少内皮粘附分子 (VCAM-1 和 ICAM-1 蛋白) 表达来抑制白细胞与人内皮细胞 (类固醇剥夺的 HUVEC) 的粘附[2]。 Medroxyprogesterone acetate (10 和 0.5 nM，2 小时) 可减少类固醇剥夺的 HUVEC 中的 NF-κB 核转位[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Medroxyprogesterone acetate (5 mg/kg，灌胃，大鼠) 显示 Cmax 为 377.9 ng/mL，AUC0- 2535.9 ng·h/mL，t1/2 为 10.2 小时[3]。Medroxyprogesterone acetate (0.05-0.2 mg/kg/天，口服，14 天，大鼠) 会增加除肾上腺之外的所有组织中的异孕酮水平，并影响海马中的 β-END 水平[4] 。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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研究领域：Vitamin D Related/Nuclear Receptor  |  Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：Progesterone Receptor  |  Androgen Receptor  |  Glucocorticoid Receptor  |  Endogenous Metabolite

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct;61(1-2):171-80.[2]. Simoncini T, et al. Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology. 2004 Dec;145(12):5745-56. [3]. Smith D, et al. Pharmacokinetics and bioavailability of medroxyprogesterone acetate in the dog and the rat. Biopharm Drug Dispos. 1993 May;14(4):341-55. [4]. Bernardi F, et al. Progesterone and medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels. Neuroendocrinology. 2006;83(5-6):348-59.