Chebulagic acid 

MCE 国际站：Chebulagic acid

中文名：诃子鞣酸

CAS：23094-71-5

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Chebulagic acid 是一种 COX-LOX 双重抑制剂，从 Terminalia chebula Retz 的果实中分离出来，抑制血管生成。 Chebulagic acid 是一种 M2 丝氨酸至天冬酰胺 31 突变 (S31N) 抑制剂和流感抗病毒药。 Chebulagic acid 还可以对抗 SARS-CoV-2 病毒复制，EC₅₀ 为 9.76 μM。

体外：Chebulagic acid 可以增强细胞自噬。 Chebulagic acid 具有抗炎和抗感染作用。 Chebulagic acid 还显示出对 1-methyl-4-phenylpyridinium (MPP+) 诱导的细胞毒性的保护作用，这种细胞毒性模仿帕金森病的病理症状。 Chebulagic acid 以剂量和时间依赖性方式抑制 LPS 诱导的 TNF-α 和 IL-1β 上调。此外，在 EA.hy926 细胞中，LPS 激活的 MAPK 信号被 Chebulagic 酸处理抑制。

热销产品：I-BET151  | GNE-7915  | Fenofibrate  | 5-Aminolevulinic acid (hydrochloride)  | Gambogenic acid  | N-Formyl-Met-Leu-Phe  | Hyocholic Acid  | Pomalidomide  | Gelucire 44/14  | Vismodegib

研究领域：Immunology/Inflammation  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：COX  |  Lipoxygenase  |  SARS-CoV  |  Influenza Virus

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Kim HJ et al. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol Ther (Seoul). 2014 Jul;22(4):275-81.[2]. Liu Y et al. Chebulagic acid inhibits the LPS-induced expression of TNF-α and IL-1β in endothelial cells by suppressing MAPK activation. Exp Ther Med. 2015 Jul;10(1):263-268.[3]. Athira AP et al. Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor. Int J Vasc Med. 2013;2013:843897.[4]. Maggie C. Duncan, et al. Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus. Molecules 2020, 25, 2903.[5]. RuikunDu, et al. Discovery of Chebulagic Acid and Punicalagin as Novel Allosteric Inhibitors of SARS-CoV-2 3CLpro. Antivir Res. 2021, 105075.

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