提出问题：Despite their important roles, the molecular mechanisms underlying early‐stage endosperm and embryo development remain elusive. 

主要发现：Here, we established the fundamental functions of rice OsLFR, an ortholog of the Arabidopsis SWI/SNF chromatin remodeling complex (CRC) component LFR.

结果1-表达模式：OsLFR was expressed primarily in the rice spikelets and seeds, and the OsLFR protein localized in the nucleus.

结果2-功能鉴定：We conducted genetic, cellular, and molecular analyses of loss‐of‐function mutants and transgenic rescue lines. OsLFR depletion resulted in homozygous lethality in the early seed stage due to endosperm and embryo defects, which could be successfully recovered by the OsLFR genomic sequence. Cytological observations revealed that the oslfr endosperm had relatively fewer free nuclei, abnormal and arrested cellularization, and premature programmed cell death; the embryo was reduced in size and failed to differentiate.

结果3-RNA-seq：Transcriptome profiling showed that many genes, involved in DNA replication, cell cycle, cell wall assembly, and cell death, were differentially expressed in a knock‐out mutant of OsLFR (oslfr‐1), which was consistent with the observed seed defects.

结果4-互作蛋白：Protein‐protein interaction analysis showed that OsLFR physically interacts with several putative rice SWI/SNF CRC components.

结论：Our findings demonstrate that OsLFR, possibly as one component of the SWI/SNF CRC, is an essential regulator of rice seed development and provide further insights into the regulatory mechanism of early‐stage rice endosperm and embryo development.