pnas.org[PDF]… , DP Liu, W Liu, JC Chang, YW … - Proceedings of the …, 1989 - National Acad Sciences ... Human fi-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site (Southern blot/ribonuclease protection assay/tissue-specific expression) PETER T. CURTIN*, DEPEI LIU*t, WEN LIu*, JUDY C. CHANG*, AND YUET WAI KAN* ... Cited by 110 - Related articles - All 9 versions
HL Li, DP Liu, CC Liang - Journal of molecular medicine, 2003 - Springer ... De-Pei Liu received his Ph.D. in bio- chemistry and molecular biol- ogy from Peking Union Medical College. ... His major research interests include gene regulation of globin gene clus- ters, gene therapy, and cardio- vascular diseases. ... Cited by 81 - Related articles - BL Direct - All 5 versions
CM Liu, DP Liu, WJ Dong, CC Liang - Biochemical and biophysical …, 2004 - Elsevier RNA interference (RNAi) is the mechanism of sequence-specific, post-transcriptional gene silencing initiated by short interfering RNAs (siRNAs) homologous to the gene being suppressed. siRNAs, which mediate sequence-specific mRNA degradation, are duplexes of about ... Cited by 47 - Related articles - All 5 versions
nih.gov[HTML]GH Wei, DP Liu, CC Liang - Biochemical Journal, 2004 - ncbi.nlm.nih.gov One of the foremost challenges in the post-genomic era will be to chart the gene regulatory networks of cells, including aspects such as genome annotation, identification of cis-regulatory elements and transcription factors, information on protein–DNA and protein–protein interactions, ... Cited by 41 - Related articles - BL Direct - All 8 versions
nih.gov[HTML]… Watt, KSE Cheah, JD Huang, DP Liu, … - Proceedings of the …, 2005 - National Acad Sciences Targeted gene modification mediated by single-stranded oligonucleotides (SSOs) holds great potential for widespread use in a number of biological and biomedical fields, including functional genomics and gene therapy. By using this approach, specific genetic changes have been ... Cited by 41 - Related articles - All 14 versions
uga.edu[PDF]XS Ke, CM Liu, DP Liu, CC Liang - Current opinion in chemical biology, 2003 - Elsevier Four decades ago, the Central Dogma was formulated and simplified as 'DNA makes RNA, and RNA makes protein'. As a result, RNAs have been looked as simple molecules that merely convert genetic information into protein. However, it has been estimated that although most of the ... Cited by 38 - Related articles - All 8 versions
ZH Li, DP Liu, WX Yin, ZC Guo, CC Liang - Blood Cells, Molecules, and …, 2001 - Elsevier An RNA/DNA chimeric oligonucleotide was found to be effective in the targeted correction of point mutations in Escherichia coli, plant, and mammalian genomes. This strategy, named chimeraplasty, has the potential for gene therapy of many genetic diseases caused by ...
HC Zhan, DP Liu, CC Liang - Human genetics, 2001 - Springer Abstract An insulator or boundary element is a novel class of regulatory sequence and has properties consistent with a role in limiting enhancer activity; it helps to define the boundary between differentially regulated loci. Origi- nally, an insulator was defined operationally by its ability to protect ... Cited by 23 - Related articles - BL Direct - All 4 versions
AB Wang, DP Liu, CC Liang - Experimental cell research, 2003 - Elsevier Apolipoprotein B is a large, amphipathic protein that plays a central role in lipoprotein metabolism. Because its overproduction and deficiency leads to metabolic and pathologic disorders, much effort has been paid to investigate the mechanisms of how its ... Cited by 23 - Related articles - All 5 versions
Y Huang, DP Liu, L Wu, TC Li, M Wu, DX Feng, … - Blood Cells, Molecules, …, 2000 - Elsevier ... 1989) p. 9–31 . 26. QH Liu, DPLiu, YZ Ding, QZ Wei, PC Jia, SS Chen and CC Liang, Expression of human β-globin gene with erythroid enhancer in transgenic mouse. Sci. China B 37 (1994), pp. 20–25. 27. M. Bulger, JH van ... Cited by 30 - Related articles - BL Direct - All 4 versions
N Zhao, DP Liu, CC Liang - Molecular biotechnology, 2001 - Springer Adeno-associated virus (AAV) is a promising viral vector in treating many kinds of hereditary diseases. The broad host range, low level of immune response, and longevity of gene expression observed with this vector have enabled the initiation of a number of clinical trials using ... Cited by 17 - Related articles - BL Direct - All 6 versions
XS Wu, DP Liu, CC Liang - Journal of Biomedical Science, 2001 - Springer Abstract A strategy called targeted gene repair was developed to facilitate the process of gene therapy using a chimeric RNA-DNA oligonucteotide. Experiments demonstrated the feasibility of using the chimeric oligonucleotide to introduce point conversion in genes in vitro and in ... Cited by 14 - Related articles - BL Direct - All 5 versions
nih.gov[HTML]MSY Huen, X Li, LY Lu, RM Watt, DP Liu, … - Nucleic acids …, 2006 - Oxford Univ Press Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential for use in functional genomic studies and gene therapy. Genetic changes have been created using this approach in a number of prokaryotic and eukaryotic systems, including mouse ... Cited by 16 - Related articles - BL Direct - All 13 versions
HC Wong, MC Chen, SH Liu, DP Liu - International journal of food …, 1999 - Elsevier ... H. -C. Wong Corresponding Author Contact Information , E-mail The Corresponding Author , a , M. -C. Chen b , S. -H. Liu a and D. -P. Liu c. ... (1997a) the clinical originated urease positive strains show stronger correlation with the trh gene than with the tdh gene. ... Cited by 48 - Related articles - All 8 versions
CM Liu, DP Liu, CC Liang - Journal of molecular medicine, 2002 - Springer Point or highly localized mutations cause many mono- genic diseases which can be corrected by gene replace- ment or gene repair. In gene replacement therapy a thera- peutic gene usually mediated by virus is transferred to the cell or affected organ. Unlike gene replacement, ... Cited by 11 - Related articles - BL Direct - All 6 versions
XH Fu, DP Liu, CC Liang - Experimental cell research, 2002 - Elsevier ... Curr. Opin. Gene Dev. 10 (2000), pp. 199–203. Article | PDF (117 K) | View Record in Scopus | Cited By in Scopus (57). 16. XG Li, DPLiu and CC Liang, Beyond the locus control region: New light on β-globin locus regulation. Int. J. Biol. Cell. Biol. 33 (2001), pp. 914–923. ... Cited by 23 - Related articles - BL Direct - All 6 versions
ZY Li, DP Liu, CC Liang - Leukemia, 2004 - nature.com ... Correspondence: Dr DPLiu, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences ... Rearrangements of the MLL gene (ALL1, HRX, and Hrtx) located at chromosome band 11q23 are commonly involved in ... Cited by 44 - Related articles - All 5 versions
MSY Huen, LY Lu, DP Liu, JD Huang - Biochemical and biophysical …, 2007 - Elsevier The λ-Red-mediated recombination has been exploited as an efficient means for DNA manipulation. We previously reported that replication plays a pivotal role during this process. Replication direction dictates strand bias, such that single stranded oligonucleotide (SSO) ... Cited by 10 - Related articles - All 7 versions
HB Zhang, DP Liu, CC Liang - International journal of hematology, 2002 - ncbi.nlm.nih.gov The alpha-globin gene cluster is located at the very tip of the short arm of chromosome 16. It produces the alpha-like globins, which is combined with the beta-like globins to form hemoglobin, and its mutants cause alpha-thalassemia, which
L Liang, DP Liu, CC Liang - European Journal of …, 2002 - interscience.wiley.com ... Science 273, 1386–1389. 12. Wu, XS, Liu, DP & Liang, CC (2001) Prospects of chimeric RNA-DNA oligonucleotides in gene therapy. J. Biomed. Sci. 8, 439–445. 13. Rice, MC, Czymmek, K. & Kmiec, EB (2001) The potential of nucleic acid repair in functional genomics. ... Cited by 15 - Related articles - BL Direct - All 7 versions
H Gong, CM Liu, DP Liu, CC … - Medicinal research …, 2005 - interscience.wiley.com ... Small RNAs of 22 nucleotides (nt) in length, which are ubiquitous, versatile repressors of gene expression in plants, animals, and many ... Correspondence to: De-Pei Liu, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of ...
YC Hsieh, TZ Wu, DP Liu, PL Shao, LY Chang, … - Journal of the Formosan …, 2006 - Elsevier ... Antigen shift is derived from reassortment of gene segments between viruses, and may result in an antigenically novel virus that is capable of ... first, followed by REVIEW ARTICLE Influenza Pandemics: Past, Present and Future Yu-Chia Hsieh, Tsung-Zu Wu, 1 Ding-Ping Liu, 2 Pei ... Cited by 41 - Related articles - BL Direct - All 5 versions
nih.gov[HTML]… Xin, W Song, LJ Di, G Liu, XS Wu, DP Liu, … - … and cellular biology, 2006 - Am Soc Microbiol ... at 1 and 2 in liver cells, but there is no NF-E2p45 occupancy at these sites in brain cells (GL Zhou and DPLiu, unpublished data). ... In mouse definitive erythroid cells, the fetal and adult 1 and 2 gene promoters are highly enriched with histone acetylation and H3-K4 dimethylation. ... Cited by 40 - Related articles - BL Direct - All 8 versions
Z Wang, ZJ Zhou, DP Liu, JD Huang - Biochemical and biophysical …, 2006 - Elsevier Single-stranded DNA oligonucleotide (SSO)-mediated gene repair has great potentials for gene therapy and functional genomic studies. However, its underlying mechanism remains unclear. Previous studies from other groups have suggested that DNA damage response ... Cited by 8 - Related articles - All 7 versions
WJ Dong, XB Wu, DP Liu, J Li, G Liu, ZX Zu, N … - Journal of biomedical …, 2002 - Springer Abstract Adeno-associated virus (AAV)-2 was developed as a use- ful vector for human gene therapy. In this report, we ana- lyzed the integration and expression of AAV-mediated ex vivo transferred human 13-globin gene in bone marrow (BM) reconstituted mice. Recombinant ...
XB Tang, DP Liu, CC Liang - Cellular and molecular life Sciences, 2001 - Springer National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005 (PR China), Fax + 86 10 65240529, e-mail address: liudp@public.east.cn.net Cited by 8 - Related articles - BL Direct - All 5 versions