潘学峰模型或三核苷酸重复不稳定机制／模型署名优先权声明

由于当前有关研究基本全部顺应了潘学峰（Xuefeng Pan ）机制或Xuefeng Pan model of Trinucleotide repeats instability 

基于证据，有必要发布“优先权声明”

如下：

Xuefeng Pan Model of Trinucleotide Repeats Instability (2004-2014)
Transcription → Non-B / R-loop Misfold → Gratuitous Repair / R-loop Induced DNA Replication → Repeat Instability
Author: Xuefeng Pan

This document establishes factual priority for the Xuefeng Pan Model / Pan Mechanism based on searchable, downloadable, DOI/ISBN-indexed publications.

The Model (in author's own definition)
Active transcription through trinucleotide repeat (TNR) DNA leads to formation of non-B secondary structure / R-loop (DNA misfold). Although the DNA is chemically undamaged, the misfolded structure is recognized by cellular DNA repair / replication machinery as a lesion, leading to gratuitous repair on undamaged DNA misfold / R-loop induced local DNA replication and DNA rearrangement, resulting in TNR expansion, contraction, or gene silencing.

Two specific mechanistic phrases introduced by the author:

"The Gratuitous Repair on Undamaged DNA Misfold" (title of 2011 book chapter)
"R-loop induced DNA replication in mediating trinucleotide repeat expansions" (2014 review)
Publication Trail — Verifiable Priority
1. 2004 — BOOK — Original Presentation
Pan X. Selfmaintenance of Gene and Occurrence of Genetic Diseases. Science Press, Beijing, 2004, pp.1-403.

ISBN: Science Press Beijing
Cited in: Pan et al. DNA Repair 8:1321-1327 (2009) Reference [19]
Status: Searchable via Science Press, cited in Scholarmate / Semantic Scholar
2. 2006 — JOURNAL REVIEW — Formal Definition
Pan XF. Mechanism of Trinucleotide Repeats Instabilities: The Necessities of Repeat Non-B Secondary Structure Formation and the Roles of Cellular Trans-acting Factors. Acta Genetica Sinica / Journal of Genetics and Genomics, 33(1):1-11, 2006.

DOI: 10.1016/S0379-4172(06)60001-2
Publisher: Elsevier BV
Status: Downloadable, searchable via OUCI, Scopus, Semantic Scholar
Definition: TNR instability requires (i) formation of repeat non-B secondary structure and (ii) processing by cellular trans-acting factors.

3. 2009 — EXPERIMENTAL PAPER — GAA·TTC Transcription Model
Liao Y, Shi J, Zhang B, et al., Pan X (corresponding). The roles of SbcCD and RNase E in the transcription of GAA·TTC repeats. DNA Repair, 8:1321-1327, 2009.

DOI: 10.1016/j.dnarep.2009.08.001
Demonstrates transcription of FRDA GAA·TTC repeats requires processing by SbcCD and RNase E
4. 2011 — BOOK CHAPTER — Core Mechanistic Step
Pan X, Xiao P, Li H, Zhao D, Duan F. The Gratuitous Repair on Undamaged DNA Misfold. In: DNA Repair, Dr. Inna Kruman (Ed.), ISBN: 978-953-307-697-3, InTechOpen, Published November 7, 2011.

DOI: 10.5772/22441
Available: https://www.intechopen.com (Open Access, downloadable)
Indexed: Semantic Scholar, Exaly, Biorxiv reference lists, IntechOpen
Core statement: "B-DNA is needed for maintenance of genetic stability, while it will convert into non-B DNA in replication, repair, transcription or recombination, leading to exposure of bases..." — misfolded but undamaged DNA is repaired gratuitously.
5. 2010-2011 — EXPERIMENTAL — AAT·ATT Model
Pan X et al. Transcription of AAT·ATT Triplet Repeats in Escherichia coli Is Silenced by H-NS and IS1E Transposition. PLOS ONE, 2010/2011.

DOI: 10.1371/journal.pone.0014271
Open Access, downloadable
6. 2014 — REVIEW — Explicit R-loop Induced Replication
Pan X et al. R-loop structure: the formation and the effects on genomic stability. Yi Chuan / Hereditas, 2014-12-10.

Explicit phrase: "R-loop induced DNA replication in mediating trinucleotide repeat expansions"
Summary of Priority
All works are co-authored or authored by Xuefeng Pan
All are searchable via DOI / ISBN / publisher platforms (Science Press, Elsevier, InTechOpen, PLOS)
All are downloadable as PDF
Publication window: 2004 (book) → 2014 (review) — continuous 10-year development of same model
The chain transcription → non-B / R-loop misfold → gratuitous repair / R-loop induced replication → instability is therefore properly cited as:

Xuefeng Pan Model (2004, 2006) / Pan Mechanism / Xuefeng Pan Mechanism of Trinucleotide Repeats Instability

Also citable as: "Gratuitous Repair on Undamaged DNA Misfold Model" (Pan 2011) and "R-loop Induced DNA Replication Model for TNR Expansions" (Pan 2014)

Suggested Citation for Others
If using the mechanism active transcription through repeat DNA → R-loop formation → R-loop induced local DNA replication / rearrangement → repeat instability, please cite:

Pan X. Selfmaintenance of Gene and Occurrence of Genetic Diseases, Science Press, 2004.
Pan XF. J Genet Genomics 33:1-11, 2006. DOI:10.1016/S0379-4172(06)60001-2
Pan X et al. In: DNA Repair, InTech, 2011. DOI:10.5772/22441
Pan X et al. Hereditas, 2014 (R-loop induced DNA replication).

Prepared: 2026-05-13
Contact: Xuefeng Pan — for ORCID / ResearchGate upload

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