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[转载]JMCB类器官专辑 | 精准搭建人体器官微模型
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类器官是一种由不同类型干细胞通过自组织方式制备，能够模拟原生器官结构和功能的一类三维“微器官模型”。相比传统的二维培养模型，类器官代表着一种能够概括整个生物体生理过程的创新技术，具有更接近生理细胞组成和行为、更稳定的基因组、更适合于生物转染和高通量筛选等优势。而与动物模型相比，类器官模型的操作更简单，还能用于研究疾病发生和发展等机理。针对该领域的研究进展及应用潜力，Journal of Molecular Cell Biology (JMCB) 最新推出了类器官专辑。
Organoids: A Powerful Tool for Modeling Human Lives
Editorial│Modeling cellular polarity, plasticity, and disease disparity in 4D Author: Xuebiao Yao Authors: Kim E. Boonekamp, Talya L. Dayton, Hans Clevers First Author: Juan He Corresponding Author: Dong Gao Keywords: organoid, tissue engineering, 3D culture Authors: Fong Cheng Pan, Todd Evans, Shuibing Chen Keywords: human pluripotent stem cells, endoderm, gastrointestinal development, disease modeling Review│Tumor organoids to study gastroesophageal cancer: a primer Authors: Ramon U. Jin, Jason C. Mills targeted therapy, precision oncology, cancer model, tumor heterogeneity, cancer evolution, personalized medicine Authors: Lulu Sun, Lijian Hui Keyword: liver organoid Article│Generation of liver bipotential organoids with a small-molecule cocktail First Authors: Xin Wang, Chao Ni Corresponding Authors: Bing Zhao, Xinhua Lin Keywords: liver bipotential organoid, small-molecule cocktail, long-term expansion, progenitor cell, hepatocyte differentiation, liver regeneration Article│Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening First Author & Corresponding Author: Yuhong Du Keywords: human colon organoids, KRASG12D, 3D culture, high-throughput screening (HTS), ultra-HTS (uHTS) First Authors: Tijmen H. Booij, Wouter N. Leonhard Corresponding Author: Keywords: PKD, celastrol, pyrvinium pamoate, high-content screening, 3D Article│Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly First Authors: Xu Liu, Leilei Xu Corresponding Authors: Wenwen Wang, Xing Liu Keywords: organoids, cell division, central spindle, CENP-E, syntelin, PRC1 Highlight│Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics Authors: Lauretta A. Lacko, Shuibing Chen
https://blog.sciencenet.cn/blog-1045694-1264914.html
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