Gamma aminobutyric acid transporter subtype 1 gene knockout mice: a new model for attention deficit/hyperactivity disorder

Ping Yang, Guoqiang Cai, Youqing Cai, Jian Fei and Guoxiang Liu

School of Life Sciences and Technology, TongJi University, Shanghai 200092, China

Acta Biochim Biophys Sin 2013, 45: 578–585; doi: 10.1093/abbs/gmt043

Attention deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impaired sustained attention, impulsivity, and is usually accompanied by varying degrees of learning difficulties and lack of motor coordination. However, the pathophysiology and etiology of ADHD remain inconclusive so far. Our previous studies have demonstrated that the gamma aminobutyric acid transporter subtype 1 (GAT1) gene knockout (ko) mouse (gat1−/−) is hyperactive and exhibited impaired memory performance in the Morris water maze. In the current study, we found that the gat1−/− mice showed low levels of attentional focusing and increased impulsivity. In addition, the gat1−/− mice displayed ataxia characterized by defects in motor coordination and balance skills. The hyperactivity in the ko mice was reduced by both methylphenidate and amphetamine. Collectively, these results suggest that GAT1 ko mouse is a new animal model for ADHD studying and GAT1 may be a new target to treat ADHD.

gat12/2 mice showed poorer attentional focusing in incentive runway test

全文: http://abbs.oxfordjournals.org/content/45/7/578.full.pdf+html 

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