ABBS博客分享 自由的小鱼


ABBS: Glucocorticoid affects peripheral circadian rhythm

已有 964 次阅读 2019-8-19 11:53 |个人分类:期刊新闻|系统分类:论文交流| glucocorticoid, dexamethasone

Time-dependent glucocorticoid administration differently affects peripheral circadian rhythm in rats

Tao Wu and Zhengwei Fu

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China

Acta Biochim Biophys Sin 2017, 49: 1122–1128; doi: 10.1093/abbs/gmx115

There is a growing recognition that glucocorticoid (GC) acts as an internal timing signal for peripheral circadian oscillators. However, the transcription process of GC-related clock gene in the peripheral tissues is not fully understood. The present study was designed to explore the potential role of clock genes in the GC-induced peripheral circadian gene expression in vivo. Real-time RT-PCR analysis indicated that the transcript levels of Per1 and Dec1 were rapidly up-regulated within 0.5 and 1 h in the heart and kidney respectively after stimulation with dexamethasone (Dex). These results suggest that Per1 and Dec1 serve as the primary and secondary responsers respectively in initiating the GC-induced peripheral circadian gene expression. By comparing the effects of the different GC administration schedules on the circadian rhythm of clock genes in peripheral tissues in rats, we found that the circadian phases of Bmal1 and Per1 were shifted more in the ZT0 (endogenous valley time) Dex stimulation group than in the ZT12 (endogenous peak time) Dex stimulation group in heart and kidney under the normal LD cycle. Under the jet lag condition, the circadian phases of Bmal1 and Per1 were also shifted more in the ZT0 Dex stimulation group than in the ZT12 Dex stimulation group. Therefore, the GC stimulation in the endogenous valley time caused circadian disorder in the normal LD cycle, but it might benefit the circadian resetting of peripheral clocks under the LD reversal condition.


Effect of Dex stimulation on circadian rhythm of clock genes




1 Resetting of circadian time peripheral tissues by glucocorticoid signaling

2 Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation

3 Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

4 The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

Glucocorticoid regulation of the circadian clock modulates glucose homeostasis

6 Keeping circadian time with hormones

Circadian Clocks, Stress, and Immunity

Endocrine regulation of circadian physiology


上一篇:ABBS: miR-219a-5p inhibits breast cancer
下一篇:ABBS: TAR cloning of biosynthetic gene cluster


该博文允许注册用户评论 请点击登录 评论 (0 个评论)


Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2021-2-27 18:06

Powered by

Copyright © 2007- 中国科学报社