哺乳动物的SWI/SNF样的Brg1/Brm相关因子(BAF)染色质重建复合体能够利用三磷酸腺苷(ATP)产生的能量改变染色质的结构，并且调节转录等核内反应.BAF复合体由很多亚基组成,具有较高的功能特异性。本文阐述了BAF复合体在哺乳动物发育以及癌症发生过程中的作用和功能，也讨论了BAF复合体功能多样性和特异性的分子机制。

图例: Brg1/BAF在Shh通路的双重功能

Diverse functions of ATP-dependent chromatin remodeling complexes in development
and cancer

Jiang I. Wu

Department of Physiology and Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9133, USA

Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to change chromatin structures and regulate nuclear processes such as transcription. BAF complexes contain multiple subunits and the diverse subunit compositions provide functional specificities to BAF complexes. In this review, we summarize the functions of BAF subunits during mammalian development and in progression of various cancers. The mechanisms underlying the functional diversity and specificities of BAF complexes will be discussed.

Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):54-69. doi: 10.1093/abbs/gmr099.

全文: http://abbs.oxfordjournals.org/content/44/1/54.full.pdf+html