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ABBS: Cannabidiol affects Alzheimer disease

已有 483 次阅读 2019-4-16 13:56 |个人分类:期刊新闻|系统分类:论文交流| cannabidiol, PPARgamma, neuroinflammation

Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease

Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, and Jean-Noël Vallée

Experimental and Clinical Neurosciences Laboratory, INSERM U1084, University of Poitiers, Poitiers, France & Laboratoire de Mathématiques et Applications (LMA), UMR CNRS 7348, Université de Poitiers, Poitiers, France

Acta Biochim Biophys Sin 2017, 49: 853–866; doi: 10.1093/abbs/gmx073

Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary plaque deposits. AD shows oxidative stress and chronic inflammation. In AD, canonical Wingless-Int (Wnt)/β-catenin pathway is downregulated, whereas peroxisome proliferator-activated receptor γ (PPARγ) is increased. Downregulation of Wnt/β-catenin, through activation of glycogen synthase kinase-3β (GSK-3β) by Aβ, and inactivation of phosphatidylinositol 3-kinase/Akt signaling involve oxidative stress in AD. Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid from Cannabis sativa plant. In PC12 cells, Aβ-induced tau protein hyperphosphorylation is inhibited by CBD. This inhibition is associated with a downregulation of p-GSK-3β, an inhibitor of Wnt pathway. CBD may also increase Wnt/β-catenin by stimulation of PPARγ, inhibition of Aβ and ubiquitination of amyloid precursor protein. CBD attenuates oxidative stress and diminishes mitochondrial dysfunction and reactive oxygen species generation. CBD suppresses, through activation of PPARγ, pro-inflammatory signaling and may be a potential new candidate for AD therapy.

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Schema of interactions between Aβ and energetic cellular metabolism in AD

阅读原文: http://www.abbs.org.cn/arts.asp?id=4209

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