Xue, S. et al . RNA regulons in Hox 5′ UTRs confer ribosome specificity to gene regulation,Nature http://dx.doi.org/10.1038/nature14010 ( 2014 ). 这篇文章报道了,核糖体对基因表达调控的分子机制。其中关键是 5′ UTRs 区的类似病毒的内部核糖体进入位点( inter ...
A Genome-Wide Screen for Genetic Variants That Modify the Recruitment of REST to Its Target Genes http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002624 该文摘要里的一段:Increasing numbers of human diseases are being linked to genetic variants, but our understanding of th ...
第一次看到这个名词:insulator element(金山词霸把它译成绝缘体) A role for insulator elements in the regulation of gene expression response to hypoxia Nucl. Acids Res. (2012) 40(5): 1916-1927 first published online November 8, 2011 doi:10.1093/nar/gkr842 摘要:Hypoxia inducible factor (HIF) up- ...
Evolution at Two Levels: On Genes and Form Evolution at Two Levels On Genes and Form.pdf 本文的核心观点:基因表达调控序列的变异,在进化中更重要."I will develop the argument, on the basis of theoretical considerations and a rapidly expanding body of empirical st ...