本文的核心观点:基因表达调控序列的变异,在进化中更重要."I will develop the argument, on the basis of theoretical considerations and a rapidly expanding body of empirical studies, that regulatory sequence evolution must be the major contributor to the evolution of form."
标题中的gene应该指基因本身,基因本身的进化,即它表达调控方式的改变;
Form是指基因的形式发生改变,例如编码序列的改变,或者拷贝数的增加等.
上面那边文章是这篇勾引出来的
Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB
该文的结论:We conclude that changing the response of transcription factors to signalling pathways can be an important mechanism of gene regulatory evolution.