博文
进化发生在两个水平:基因和形式
|||
Evolution at Two Levels: On Genes and Form
本文的核心观点:基因表达调控序列的变异,在进化中更重要."I will develop the argument, on the
basis of theoretical considerations and a rapidly expanding body of empirical studies, that regulatory
sequence evolution must be the major contributor to the evolution of form."
basis of theoretical considerations and a rapidly expanding body of empirical studies, that regulatory
sequence evolution must be the major contributor to the evolution of form."
标题中的gene应该指基因本身,基因本身的进化,即它表达调控方式的改变;
Form是指基因的形式发生改变,例如编码序列的改变,或者拷贝数的增加等.
上面那边文章是这篇勾引出来的
Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB
该文的结论:We conclude that changing the response of transcription factors to signalling pathways can be an important mechanism of gene regulatory evolution.
这两篇文章表明基因表达调控的变异,非常重要,可能还很普遍.所以,在基因克隆的时候编码区没有明显的变异时,得沉得住气.可能和调控序列有关.
Tempo and Mode in Evolution of Transcriptional Regulation
https://blog.sciencenet.cn/blog-479743-518658.html
上一篇：植物对氧的感觉
下一篇：很好的CAPS标记开发的网站
