众所周知,p53 是一种肿瘤抑制基因,被广泛称为“基因组的守护者”。自 1979 年被发现至今,p53 基因一直是分子生物学和肿瘤学的研究热门。据 Elie Dolgin 在 Nature 上发表的 “The most popular genes in the human genome” 统计,截至 2017 年,PubMed 数据库中研究最多的基因列表——一种人类基因组的“热门基因”,TP53 荣得桂冠。
Gaurav Mendiratta 等人在 2021 年发表的“Cancer gene mutation frequencies for the U.S. population” 中,通过结合基因组 (所有癌症中每个基因中包含一个或多个突变的估计比例) 和流行病学数据也统计了美国人群中基因突变的频率,发现 TP53 是最常见的突变基因 (35%)。
1. Elie Dolgin, et al. The most popular genes in the human genome. Nature. 2017 Nov 23;551(7681):427-431.2. Gaurav Mendiratta, et al. Cancer gene mutation frequencies for the U.S. population. Nat Commun. 2021 Oct 13;12(1):5961.3.
Liz J Hernández Borrero 1, Wafik S El-Deiry, et al. Tumor suppressor
p53: Biology, signaling pathways, and therapeutic targeting. Biochim
Biophys Acta Rev Cancer. 2021 Aug;1876(1):188556.4. Sandra L Harris, et al. The p53 pathway: positive and negative feedback loops. Oncogene. 2005 Apr 18;24(17):2899-908.5.
David Lane, Arnold Levine, et al. p53 Research: the past thirty years
and the next thirty years. Cold Spring Harb Perspect Biol. 2010
Dec;2(12):a000893.6.
Arjelle Decasa Agupitan, Ygal Haupt, et al. P53: A Guardian of Immunity
Becomes Its Saboteur through Mutation. Int J Mol Sci. 2020 May
13;21(10):3452.7. N S Litofsky, L D Recht, et al. The impact of p53 tumor suppressor gene on glioma biology.8.
Jiandong Chen, et al. The Cell-Cycle Arrest and Apoptotic Functions of
p53 in Tumor Initiation and Progression. Cold Spring Harb Perspect Med.
2016 Mar 1;6(3):a026104.9.
Alexei Vazquez, Gareth L Bond, et al. The genetics of the p53 pathway,
apoptosis and cancer therapy. Nat Rev Drug Discov. 2008
Dec;7(12):979-87.10. Y Xie, R Kang, D Tanget al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79.11.
Patrick Chène, et al. Inhibiting the p53-MDM2 interaction: an important
target for cancer therapy. Nat Rev Cancer. 2003 Feb;3(2):102-9.12.
Wen Xue, et al. Senescence and tumour clearance is triggered by p53
restoration in murine liver carcinomas. Nature. 2007 Feb
8;445(7128):656-60.13.
Xiaolei Zhou, Galina Selivanova, et al. Pharmacological activation of
p53 triggers viral mimicry response thereby abolishing tumor immune
evasion and promoting anti-tumor immunity. Cancer Discov. 2021 Jul
6;candisc.1741.2020.14.
Le Jiang, Wei Gu, et al. Ferroptosis as a p53-mediated activity during
tumour suppression. Nature. 2015 Apr 2;520(7545):57-62.15.
Bo Chu, Wei Gu, et al. ALOX12 is required for p53-mediated tumour
suppression through a distinct ferroptosis pathway. Nat Cell Biol. 2019
May;21(5):579-591.
16.
Delin Chen, Wei Gu, et al. iPLA2β-mediated lipid detoxification
controls p53-driven ferroptosis independent of GPX4. Nat Commun. 2021
Jun 15;12(1):3644.