Background TRIM (Tripartite Motif) proteins are a large family of E3 ubiquitin ligases involved in immunity, development, intracellular signaling, and disease. They share a conserved modular architecture containing a RING domain, B-box(es), coiled-coil (CC) domain, and variable C-terminal domains. A ...
Background Molecular binding in liquids is fundamental to many processes in chemistry, soft matter, and biology, including viral attachment, transcription factor binding, enzymatic reactions, self-assembly, and drug interactions. Traditionally, binding dynamics have been modeled as memoryless ...
Picture from The nucleolus as a multiphase liquid condensate | Nature Reviews Molecular Cell Biology Across the cell cycle, the nucleolus is not a static body but a highly dynamic condensate whose organization is tightly coupled to ribosome biogenesis and cell-cycle state. ...
Background This study addresses a central question in chromosome biology: how the 3D genome is rebuilt when cells exit mitosis and re-enter G1 phase. During mitosis, transcription is broadly suppressed and higher-order chromatin organization is extensively disrupted. Although previous work ...
Background Three major SMC-complex activities shape chromosome architecture in mammalian cells: extrusive cohesin , which drives loop extrusion and supports TADs/loops in interphase; cohesive cohesin , which holds sister chromatids together; and condensins , which organize mitotic ch ...
Background Higher-order chromatin structures (A/B compartments, TADs, and loops) are largely disrupted during mitosis and must be re-established after cell division. However, the temporal order, mechanisms, and dependencies of this reorganization remain unclear, especially how different archi ...
Background The genome is normally organized into A/B compartments, TADs, and chromatin loops, but the mechanisms that actually drive compartment formation and separation are still not fully understood. This is especially unclear because, in interphase, many factors act at the same time, inclu ...
肾细胞癌基因转位导致TFE3融合基因形成可促进肿瘤恶性进展。TFE3常与PRCC、NONO、SFPQ等基因发生融合，形成新的融合蛋白。然而TFE3融合蛋白如何驱动肿瘤恶性进展尚不清楚。近期研究表明，TFE3-NONO融合蛋白可形成相分离凝聚体，并促进融合蛋白稳定性其在肿瘤染色质调节及基因转录调控中的作用尚不清楚。 最近，Dengfeng C ...
2025 年诺贝尔生理学或医学奖：免疫系统的平衡与智慧
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