本期刊·见为大家介绍生物学领域期刊Animal Cells and Systems。本刊是韩国综合生物学会（Korean Society for Integrative Biology）的官方期刊。期刊内容涵盖生物学的各个方面，包括发育、分子和细胞，旨在为生物学的研究提供信息并推动其发展。

除了对期刊进行详尽的介绍外，还向您介绍刊内近三年高被引文章，以及近一年高阅读量文章：

• Broussonetia kazinoki提取物Kazinol C可通过内质网应激介导的信号刺激自噬作用

• 人类疾病中内质网应激反应与自噬之间的相互关系

• 使用含抗坏血酸的成熟培养基人类多功能干细胞中有效衍生心室心肌细胞

Print ISSN: 1976-8354 Online ISSN: 2151-2485

访问期刊主页：Animal Cells and Systems

Animal Cells and Systems发表与动物科学和生物学、进化论、生态学、生物化学、遗传学和基因组学相关的全球研究成果。包括但不仅限于以下研究领域：

• 发育生物学

• 进化与分子生态学

• 遗传学与基因组学

• 分子和细胞生物学

• 神经生物学与生理学

• 转化医学

该期刊已被SCIE, Scopus, DOAJ, PubMed Central, BIOSIS等数据库收录。

影响因子

根据JCR显示，Animal Cells and Systems

• 动物学排名10/177

• 细胞生物学排名137/191

CiteScore

根据Scopus显示, Animal Cells and Systems

• CiteScore（2022）为4.0

• CiteScoreTracker（2023）为4.5

农业与生物科学：

• 动物科学与动物学领域排名90/456

• 生物化学、遗传学和分子生物学：

• 普通生物化学、遗传学和分子生物学领域排名84/212

中国科学院分区表

根据2023年12月27日发布的中国科学院文献情报中心期刊分区表（升级版）显示：

大类及分区：生物学2区

小类及分区：

• 细胞生物学3区

• 动物学2区

作者须知

收稿文章类型

Animal Cells and Systems发表以下类型的文章：

• 研究文章

• 综述

Animal Cells and Systems对所有稿件的审核条件非常严格。即，稿件仅能投给Animal Cells and Systems且尚未发表，也未在其他地方发表或付印。

审稿周期

• 从提交稿件到获取初审意见，平均需要10天

• 获取首个同行评审决定，平均需要24天

• 稿件一旦接受后，在线出版平均需要9天

文章出版费（APC）

请访问期刊主页或Taylor & Francis Open Access APC Cost Finder查找适用于作者所在国家及不同文章类型的费用情况。若您所在的机构或相关资助者与我们签有开放获取出版协议，您可能有资格获得APC支持，请访问我们的作者服务网站以了解更多！

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编辑团队

Animal Cells and Systems的主编由Joohong Ahnn（韩国汉阳大学）担任，副主编一共为9名，此外，编委由多国研究人员组成。

主编介绍

Joohong Ahnn

韩国汉阳大学生命科学系教授，发育遗传学实验室负责人。主要研究方向：钙及其结合蛋白诱导的细胞生理变化引起的动物发育和与感觉神经系统有关的动物行为变化。

作者分布

根据JCR显示，近三年在Animal Cells and Systems发文的国家中，发文数量排名前三位的是：

• 韩国

• 中国

• 美国

近三年，在Animal Cells and Systems发文的全球高校和科研机构中，发文数量排名前三位的是：

• 韩国高丽大学

• 韩国首尔大学

• 韩国忠南国立大学

近三年内高被引文章

Broussonetia kazinoki提取物Kazinol C可通过内质网应激介导的信号刺激自噬作用

作者：Yunkyeong Lee et al.

Autophagy induction upon treatment with the natural compound Kazinol C (KC).

文章摘要：

Autophagy modulators are considered putative therapeutic targets because of the role of autophagy in cancer progression. Kazinol C, a 1,3-diphenylpropane from the plant Broussonetia kazinoki, has been shown to induce apoptosis in colon cancer cells through the activation of AMPK at high concentrations. In the present study, we found that Kazinol C induced autophagy through endoplasmic reticulum stress-mediated unfolded protein response signaling in several normal and cancer cell lines at low concentrations of Kazinol C that did not induce apoptosis. Kazinol C activated the transducers of unfolded protein response signaling, leading to target gene expression, LC3-II conversion, and TFEB nuclear translocation. Chemical inhibition of endoplasmic reticulum stress reduced LC3-II conversion. In addition, blockade of autophagy by knockout of Atg5 or treatment with 3-MA enhanced Kazinol C-induced apoptosis. In summary, we have uncovered Kazinol C as a novel autophagy inducer and confirmed the role of autophagy as a cellular stress protector.

人类疾病中内质网应激反应与自噬之间的相互关系

作者：Junhee Kwon et al.

文章摘要：

Cells activate protective mechanisms to overcome stressful conditions that threaten cellular homeostasis, including imbalances in calcium, redox, and nutrient levels. Endoplasmic reticulum (ER) stress activates an intracellular signaling pathway, known as the unfolded protein response (UPR), to mitigate such circumstances and protect cells. Although ER stress is sometimes a negative regulator of autophagy, UPR induced by ER stress typically activates autophagy, a self-degradative pathway that further supports its cytoprotective role. Sustained activation of ER stress and autophagy is known to trigger cell death and is considered a therapeutic target for certain diseases. However, ER stress-induced autophagy can also lead to treatment resistance in cancer and exacerbation of certain diseases. Since the ER stress response and autophagy affect each other, and the degree of their activation is closely related to various diseases, understanding their relationship is very important. In this review, we summarize the current understanding of two fundamental cellular stress responses, the ER stress response and autophagy, and their crosstalk under pathological conditions to help develop therapies for inflammatory diseases, neurodegenerative disorders, and cancer.

Endoplasmic Reticulum (ER) stress induces unfolded protein response (UPR) as a recovery mechanism in cells.

近一年内高阅读量文章

使用含抗坏血酸的成熟培养基从人类多功能干细胞中有效衍生心室心肌细胞

作者：Ji-eun Kim et al.

Cardiomyocyte differentiated from hPSC via temporal regulation of Wnt signaling.

文章摘要：

Cardiomyocytes derived from human pluripotent stem cells (hPSCs) can be used in various applications including disease modeling, drug safety screening, and novel cell-based cardiac therapies. Here, we report an optimized selection and maturation method to induce maturation of cardiomyocytes into a specific subtype after differentiation driven by the regulation of Wnt signaling. The medium used to optimize selection and maturation was in a glucose starvation conditions, supplemented with either a nutrition complex or ascorbic acid. Following optimized selection and maturation, more cardiac Troponin T (cTnT)-positive cardiomyocytes were detected using albumin and ascorbic acid than B27. In addition, ascorbic acid enriched maturation of ventricular cardiomyocytes. We compared cardiomyocyte-specific gene expression patterns under different selection and maturation conditions by next-generation sequencing (NGS) analysis. Our optimized conditions will enable simple and efficient maturation and specification of the desired cardiomyocyte subtype, facilitating both biomedical research and clinical applications.

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