本文已经发表在《英国放射学杂志》

去年日本医科大学太田小组已经发表类似论文。本次文章来自日本大阪大学Kenya Murase小组，不是一个单位，尽管都在东京。本研究采用了一个新的检测方法，对动物进行了多层螺旋CT动态增强扫描（dynamic contrast-enhanced CT）检测肾脏功能，结果发现氢气水确实能保护肾脏功能，与血清学检测结果一致。没看全文，大概结果如此。

这个杂志比较一般，发表这个杂志的唯一理由是采用了这个研究方法，如果采用MRI，那么就可以走类似路子了。

明显不足是研究内容实在太少，属于填缝性论文。不过采用这个“新”技术，仍值得鼓励提倡。

Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT

A Kitamura, BSc ¹ S Kobayashi, BSc ¹ T Matsushita, BSc ¹ H Fujinawa, PhD ² and K Murase, PhD ¹

¹ Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan ² I'rom Pharmaceutical, Tokyo 141-0032, Japan

Correspondence: Dr Kenya Murase, Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.

E-mail: murase@sahs.med.osaka-u.ac.jp

Our aim was to assess the protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT (DCE-CT). DCE-CT studies were performed in 30 rats (8 weeks old) on days 0, 2, 4 and 7 using multidetector row CT. The rats were divided into three groups: a control group (n = 6) with free access to standard water and without cisplatin injection, a non-treatment group (n = 12) with free access to standard water and injected with cisplatin (3.6 mg kg^–1 body weight) intraperitoneally on day 0 and a treatment group (n = 12) with free access to hydrogen-rich water starting from 7 days before cisplatin injection. The contrast clearance per unit renal volume (K₁) was estimated from the DCE-CT data using the Patlak model. The contrast clearance of the entire kidney (K) was obtained by multiplying K₁ by the renal volume. The serum creatinine level was also measured on day 7. The K₁ and K values normalised by those on day 0 in the treatment group were significantly greater than those in the non-treatment group on days 2, 4 and 7. There were no significant differences in the normalised K value between the treatment and control groups on days 2 and 7. The serum creatinine level in the treatment group was significantly lower than that in the non-treatment group and was not significantly different from that in the control group. This study demonstrated that hydrogen-rich water ameliorates renal dysfunction due to cisplatin-induced nephrotoxicity in rats.

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