博文
氢气没有直接抗氧化作用？(日本健康科学)
|||
这个研究还有另外一个研究内容，就是发现尽管氢气不能直接抗氧化，但能间接通过影响生物酶活性发挥“抗氧化”的效应。按照这个研究的提示，氢气并不是什么生物抗氧化物质，而是酶调节因子，这种调节作用的能力暗示氢气可能具有生理调节功能。目前发现的所谓抗氧化、抗炎症和抗细胞凋亡效应，只不过是氢气重要调节作用的整体体现，是氢气协助并提升了细胞本身发挥对抗不利因素的能力。也许能通过影响一些酶活性、并影响代谢过程，是细胞具有对抗外来不利因素的武器。在细菌时代，有的大肠杆菌可以产生氢气，有的大肠杆菌可以把氢气转化成甲烷，甚至有的细菌（胃和肝的曲菌）可以利用氢气产生能量，氢气相对于细菌，就类似氧气和葡萄糖相对与人类。人类是从细菌进化来的高等生物，如果发现氢气对人体的基本生命过程产生重要影响，实在不足为奇。
来自日本的一个关于氢气抗氧化的文章，是通过与β━羧乙基 锗倍半氧化物和纳米白金抗氧化性能的比较研究，结果发现体外研究实验证明氢气不能中和活性氧， β━羧乙基锗倍半氧化物和纳米白金可以直接中和活性氧， 作者认为，这些具有抗氧化作用的液体，发挥作用的在体机制是不同的。这个研究是否就推翻了最近关于氢气抗氧化的观点，尽管需要更多研究，但不得不引起我们的重视。提醒我们不能盲目接受别人的观点。例如关于氢气抗氧化的基本解释：氢气与羟基自由基反应，产生水和氢原子。其中氢原子也是自由基，活性非常强，目前认为是辐射损伤的重要介质。这些问题都是我们需要注意的问题。
In Vitro Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives
Atsushi Hiraoka1), Hitomi Inaba1), Eri Suzuki1), Kazuto Kasai1), Hikaru Suzuki1), Atsuko Shinohara2), Mika Shirao3), Koshi Kubo4) and Yoshihiro Yoshimura5)
1) Faculty of Health Sciences,
2) Research Institute for Cultural Sciences,
3) Department of Human Nutrition, Jissen Women's College
4) Faculty of Pharmaceutical Sciences,
5) Nihon Integrative Medicine Institute
(Received August 28, 2009)
(Accepted January 13, 2010)
β━羧乙基锗倍半氧化物。自浅井一彦等最早报导具有抗癌活性的有机化合物Ge━132以来，佐藤博、Shimauchi、Suzuki等用它对艾氏腹水型肝癌鼠进行治疗，结果平均存活时间明显延长。80年代以来，国内学者始关注有机锗的合成及其抗癌活性。1989年，南开大学白明章等合成了15种锗倍半氧化物，并研究了它们的抗癌活性；广州军事医学研究所和广州医学院药理研究室随後也报导了Ge━132。
We studied the in vitro antioxidant activities of neutral aqueous solution systems (water products marketed as drinks) containing hydrogen gas (H2), 2-carboxyethyl germanium sesquioxide (Ge-132), and platinum (Pt) nanocolloid as additives. We evaluated the abilities of these aqueous solutions to inhibit the oxidation of biomolecules catalyzed by an enzyme and induced by reactive oxygen species (ROS) and also to scavenge ROS directly using electron spin resonance (ESR) spectrometry. The concentrations of inorganic elements including Ge and Pt were measured by inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES). All the water products examined more or less inhibited the oxidation of 3,4-dihydroxyphenylalanine by tyrosinase and that of L-histidine in an L-ascorbic acid/Cu2+ reaction system. The results of ICP-MS and ICP-AES analyses revealed that Ge, Pt, and some major minerals existed in the water products at concentrations approximately equivalent to those reported by their manufacturers. The ESR spectra indicated that the dissolved Ge-132 molecules and the supplemented Pt nanocolloid particles reduced hydroxyl and superoxide anion radicals. However, under the conditions employed, aqueous H2 did not display such a scavenging ability for these ROS. Our results suggest that H2, Ge-132 and Pt nanocolloid dissolved or supplemented in neutral aqueous media exhibited antioxidant activities in vitro due to the direct scavenging of ROS and/or by other mechanisms.
https://blog.sciencenet.cn/blog-41174-313288.html
上一篇：氢气能预防衰老引起的学习能力下降
下一篇：氢气治疗慢性氧中毒
