脓毒症是目前国际研究热点，特别是临床上十分关注，当然治疗脓毒症目前仍存在许多问题，一直没有特别大的突破。氢气作为选择性抗氧化物质，是否能治疗脓毒症，当然值得探讨。

来自中国第四军医大学麻醉学的研究表明，呼吸一定浓度（2%）6小时，可以非常有效地治疗中重度脓毒症，他们采用动物模型，通过多种器官损伤和氧化指标，证明了该效果的存在。这是国际上首次报道氢气能治疗脓毒症，不仅给脓毒症的研究提供了一个新的思路，而且扩展了氢气的生物学效应的研究范围。是非常值得阅读的重要文献。本文已经被国际著名杂志《休克》接受。

从这个研究出发，我们应该考虑采用不同的模型，采用不同的给氢气方法，继续深入研究这个课题。

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伴有急性器官功能障碍的脓毒症(严重脓毒症)是ICU病房病人死亡的第一大原因。在美国，每年大约有750,000个人发展为脓毒症，平均每天有2,000个新发病例，而全世界的总的发病数还不知晓。随着免疫抑制病人增多、侵入性治疗检查的增加、微生物耐药、老年人人口的增长和人们对脓毒症认识与诊断水平的提高，目前脓毒症的病例呈上升趋势。尽管对其治疗给予巨大的投资，严重脓毒症的死亡率还是呈上升的趋势，已经从过去的 28%上升到如今的50%。脓毒症最后导致器官功能障碍和死亡。过去，人们一直认为脓毒症是体内某细菌感染引发的系统性炎症反应的症状。今天，我们认为脓毒症不只是一种炎症反应，而是典型的系统性炎症反应、促凝血素质特异质（prothrombotic diathesis）和纤维蛋白溶解失调三位一体的表现。脓毒症一旦发生，这种三合一反应组合的发现对于降低脓毒症的发病率和死亡率有重大的意义。事实上，一旦脓毒症发生，引起严重脓毒症的恶性循环的走向与潜在的感染性疾病过程无关。

文章摘要

 Protective Effects of Hydrogen Gas on Murine Polymicrobial Sepsis via Reducing Oxidative Stress and HMGB1 Release

ABSTRACT----Despite recent advances in antibiotic therapy and intensive care, sepsis is still considered to be the most common cause of death in intensive care units (ICU). Excessive production of reactive oxygen species (ROS) plays an important role in the pathogenesis of sepsis. Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (•OH, the most cytotoxic ROS) and effectively protects against organ damage induced by ischemia/reperfusion. Therefore, we hypothesized that H2 treatment had a beneficial effect on sepsis. In the present study, we found that H2 inhalation starting at 1 and 6 hours after cecal ligation and puncture (CLP) or sham operation significantly improved the survival rate of septic mice with moderate or severe CLP in a concentration- and time-dependent manner. Furthermore, moderate or severe CLP mice showed significant multiple organ damage characterized by the increases of lung myeloperoxidase (MPO) activity, wet-to-dry (W/D) weight ratio, protein concentration in bronchoalveolar lavage (BAL), serum biochemical parameters, and organ histopathological scores at 24 hours after CLP operation, which was significantly attenuated by 2% H2 treatment. In addition, we found that the beneficial effects of H2 treatment on sepsis and sepsis-associated organ damage were associated with the decreased levels of oxidative product, increased activities of antioxidant enzymes and reduced levels of high-mobility group box 1 (HMGB1) in serum and tissue. Thus, H2 inhalation may be an effective therapeutic strategy for septic patients.