Tempo

MCE 国际站：Tempo

CAS：2564-83-2

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Tempo 是一种经典的氮氧自由基，是一种选择性的 ROS 清除剂，可在催化循环中歧化超氧化物。 Tempo 诱导 DNA 链 断裂。 Tempo 可用作伯醇氧化成醛的有机催化剂。 Tempo 具有致突变和抗氧化作用^[1][2][3][4]。

热销产品：(S,R,S)-AHPC-Me (hydrochloride)  | DSRM-3716  | Sodium 2-oxopropanoate  | RBN012759  | Procyanidin A1  | Biotin-PEG12-NHS ester  | Curzerene  | PP1  | AZ10606120 (dihydrochloride)  | Thiazole Orange

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：DNA/RNA Synthesis  |  Reactive Oxygen Species  |  Mitochondrial Metabolism

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.

[2]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773.

[3]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225.

[4]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22.