Alpha-Naphthoflavone | α-萘黄酮

MCE 国际站：Alpha-Naphthoflavone

中文名：α-萘黄酮

CAS：604-59-1

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性： Alpha-Naphthoflavone 是一种类黄酮，是一种有效的竞争性 aromatase 抑制剂，具有 IC₅₀ 和 K_i 分别为 0.5 和 0.2 μM^[1]。 IC50 和目标：IC50：0.5 μM（芳香化酶）^[1]Ki：0.2 μM（芳香化酶）^[1]

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研究领域：Metabolic Enzyme/Protease  |  Immunology/Inflammation

作用靶点：Cytochrome P450  |  Aryl Hydrocarbon Receptor

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：[1]. Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8.

[2]. Cheng YW, et al. Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):377-85.

[3]. Flores-Pérez A, et al. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018 Feb 1;281:98-105.

[4]. Hao J, et al. Resveratrol supports and alpha-naphthoflavone disrupts growth of human ovarian follicles in an in vitro tissue culture model. Toxicol Appl Pharmacol. 2018 Jan 1;338:73-82.