Wiley 旗下的 Advanced 系列期刊是全球知名、高影响力的期刊系列，致力于传播来自知名和新兴研究人员的优秀科研成果，助力研究人员实现科研使命，提升科研成果的传播力和影响力。凭借严谨的同行评审体系和卓越的出版质量，Advanced系列期刊持续引领科学前沿，促进全球科研交流与合作。

为庆祝Advanced系列期刊在生命与健康科学领域的拓展，Advanced Science 和 Advanced Biology 期刊隆重推出一系列精选文章合集。本文为大家介绍细胞与分子生物学文章合集，通过本系列精选内容展示该领域的优秀研究成果，为全球科研人员提供前沿洞见。

本次细胞与分子生物学精选文章合集涵盖5大主题，分别如下：

• Targeting Ferroptosis: Modulation Mechanisms and Therapeutic      Implications

靶向铁死亡：调控机制与治疗意义

• Biomechanics in Cellular Dynamics

细胞动力学中的生物力学

• The Dual Role of Extracellular Vesicles in Disease Dynamics and      Therapy

细胞外囊泡在疾病动态与治疗中的双重作用

• Advancing Complexity and Physiological Relevance of In Vitro      Tissue Models

提升体外组织模型的复杂性与生理相关性

• Advances in Targeted Protein Degradation

靶向蛋白降解的最新进展

下面为大家介绍每个主题的精选文章，了解文章内容，可点击链接：

https://advanced.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)2198-3844.cell-mol-bio

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主题一

Targeting Ferroptosis: Modulation Mechanisms and Therapeutic Implications

靶向铁死亡：调控机制与治疗意义

精选文章：

• Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

药理学抑制铁死亡：神经退行性疾病与中风的治疗靶点

• Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti-PD-1/L1 Response

靶向xCT介导的铁死亡及巨噬细胞促肿瘤极化：对肝细胞癌的有效性及其对抗PD-1/L1疗法的增强作用

• Malic Enzyme 1 as a Novel Anti-Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury

苹果酸酶1：肝脏缺血再灌注损伤中的新型抗铁死亡调节因子

• Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth

色氨酸代谢作为新型抗铁死亡通路调控肿瘤生长

• Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy

纳米颗粒协同铁死亡与铜死亡增强癌症免疫治疗

• Programming a Ferroptosis-to-Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

构建铁死亡至凋亡转变图谱揭示癌症治疗中的铁死亡生物标志物及抑制因子

• BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis

BRCC36 通过去泛素化 HMGCR 调控铁死亡与焦亡的相互作用

• Protective Effect of Compound Tongluo Decoction on Brain Vascular Endothelial Cells after Ischemia-Reperfusion by Inhibition of Ferroptosis Through Regulating Nrf2/ARE/SLC7A11 Signaling Pathway

复方通络汤通过调控Nrf2/ARE/SLC7A11信号通路抑制铁死亡，对脑血管内皮细胞缺血再灌注损伤具有保护作用

• Ferroptosis in Glaucoma: A Promising Avenue for Therapy

铁死亡在青光眼中的作用：潜在的治疗新途径

• Ferroptosis: A New Strategy for the Treatment of Fibrotic Diseases

铁死亡：治疗纤维化疾病的新策略

主题二

Biomechanics in Cellular Dynamics

细胞动力学中的生物力学

精选文章:

• Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction

静态与动态：调控细胞力传导的生物材料力学性能演变

• Dynamic Stimulations with Bioengineered Extracellular Matrix-Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy

利用仿生细胞外基质的生物工程水凝胶进行动态刺激，实现细胞力学重编程与治疗

• Curved Nanofiber Network Induces Cellular Bridge Formation to Promote Stem Cell Mechanotransduction

弯曲纳米纤维网络诱导细胞桥形成，促进干细胞力传导

• Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells

特定微环境触发人类多能干细胞的体外原肠胚形成

• Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells

高血压压力机械感知单独触发脂滴积累并诱导血管平滑肌细胞向泡沫细胞转分化

• Targeting Nuclear Mechanics Mitigates the Fibroblast Invasiveness in Pathological Dermal Scars Induced by Matrix Stiffening

靶向核力学调控缓解基质僵硬诱导的病理性皮肤瘢痕成纤维细胞侵袭性

• Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism

肿瘤生物力学通过重塑脂肪酸代谢改变三阴性乳腺癌的转移扩散

• Different Biomechanical Cell Behaviors in an Epithelium Drive Collective Epithelial Cell Extrusion

上皮细胞不同的生物力学行为驱动集体性细胞挤出

• 3D Micropatterned Traction Force Microscopy: A Technique to Control 3D Cell Shape While Measuring Cell-Substrate Force Transmission

3D微图案牵引力显微技术：在测量细胞-基质力传递的同时控制细胞三维形态

• High-Throughput Multiparametric Quantification of Mechanics Driven Heterogeneity in Mesenchymal Stromal Cell Population

高通量多参数定量分析力学驱动的间充质基质细胞群体异质性

主题三

The Dual Role of Extracellular Vesicles in Disease Dynamics and Therapy

细胞外囊泡在疾病动态与治疗中的双重作用

精选文章：

• Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional  Extensions

脂质纳米颗粒体内外递送治疗性VEGFA mRNA并改造细胞外囊泡以拓展其功能

• Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes  Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis

炎性成纤维样滑膜细胞来源的外泌体通过增强巨噬细胞糖酵解加重骨关节炎

• Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis

细胞外囊泡中Glypican 1 mRNA和蛋白的分析用于胰腺癌的诊断与预后评估

• High-Performance Hydrogel-Encapsulated Engineered Exosomes for Supporting Endoplasmic Reticulum Homeostasis and Boosting Diabetic Bone Regeneration

高性能水凝胶包裹工程化外泌体维持内质网稳态并促进糖尿病骨再生

• Microfluidic Biochips for Single Cell Isolation and Single Cell Analysis of Multiomics and Exosomes

微流控生物芯片用于单细胞分离及多组学与外泌体的单细胞分析

• Extracellular Vesicles from Highly Metastatic Osteosarcoma Cells Induce Pro-Tumorigenic Macrophage Phenotypes

高转移性骨肉瘤细胞来源的细胞外囊泡诱导促肿瘤巨噬细胞表型

• Closer to The Heart: Harnessing the Power of Targeted Extracellular Vesicle Therapies

贴近心脏：靶向细胞外囊泡疗法的潜能开发

• Impact of Isolation Methods on Extracellular Vesicle Functionality In Vitro and In Vivo

分离方法对细胞外囊泡体内外功能性的影响

主题四

Advancing Complexity and Physiological Relevance of In Vitro Tissue Models

提升体外组织模型的复杂性与生理相关性

精选文章：

• 3D In Vitro Blood-Brain-Barrier Model for Investigating Barrier Insults

用于研究屏障损伤的三维体外血脑屏障模型

• Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients

基于间充质基质细胞的微工程类器官芯片用于预测肝细胞癌患者的免疫治疗反应

• A T Cell-Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy

一种T细胞介导的肿瘤类器官平台用于胰腺癌免疫治疗

• Chronotoxici-Plate Containing Droplet-Engineered Rhythmic Liver Organoids for Drug Toxicity Evaluation

Chronotoxici-Plate：包含液滴工程化节律性肝类器官的药物毒性评估平台

• Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform

基于人体器官芯片平台模拟长期宇宙辐射的影响

• Recent Progress in Generation of Inner Ear Organoid

内耳类器官生成的最新进展

• In Vitro Models of Blood and Lymphatic Vessels-Connecting Tissues and Immunity

体外血管与淋巴管连接组织及免疫的模型研究

• Essential Role of Anisotropy in Bioengineered Cardiac Tissue Models

生物工程化心脏组织模型中各向异性的重要作用

• Microphysiological Models of Lung Epithelium-Alveolar Macrophage Co-Cultures to Study Chronic Lung Disease

肺上皮-肺泡巨噬细胞共培养的微生理模型用于研究慢性肺部疾病

• Special Issue: Microphysiological Systems for Precision Medicine

特刊：精准医学中的微生理系统

主题五

Advances in Targeted Protein Degradation

靶向蛋白降解的最新进展

精选文章：

• Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery  for Targeted Protein Degradation and Amplified Antitumor Effects

谷胱甘肽清除纳米粒介导的PROTAC递送：靶向蛋白降解与增强抗肿瘤效应

• Nano-LYTACs for Degradation of Membrane Proteins and Inhibition of CD24/Siglec-10 Signaling Pathway

纳米LYTACs用于膜蛋白降解及CD24/Siglec-10信号通路抑制

• Chemotherapy-Enabled Colorectal Cancer Immunotherapy of Self-Delivery Nano-PROTACs by Inhibiting Tumor Glycolysis and Avoiding Adaptive Immune Resistance

化疗增强型自递送纳米PROTACs的结直肠癌免疫治疗：抑制肿瘤糖酵解并规避适应性免疫耐受

• Drugtamer-PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy

Drugtamer-PROTAC偶联策略：靶向PROTAC递送与协同抗肿瘤治疗

• A Nucleic Acid-Based LYTAC Plus Platform to Simultaneously Mediate Disease-Driven Protein Downregulation

基于核酸的LYTAC Plus平台：同时介导疾病驱动的蛋白质下调

• Multivalent Aptamer-Based Lysosome-Targeting Chimeras (LYTACs) Platform for Mono- or Dual-Targeted Proteins Degradation on Cell Surface

多价适配体基溶酶体靶向嵌合体（LYTACs）平台：实现细胞表面单靶点或双靶点蛋白降解

• Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer

新型eEF2K降解剂的设计与特性研究：针对三阴性乳腺癌的强效治疗潜力

• Antitumor Effect of Anti-c-Myc Aptamer-Based PROTAC for Degradation of the c-Myc Protein

基于抗c-Myc适配体的PROTAC降解c-Myc蛋白的抗肿瘤作用

• Targeted Protein Degradation: Principles, Strategies, and Applications

靶向蛋白降解：原理、策略与应用