背景回顾：Plants show an unparalleled regenerative capacity, allowing them to survive severe stress conditions, such as injury, herbivory attack and harsh weather conditions. This potential not only replenishes tissues and restores damaged organs, but can also give rise to whole plant bodies. 

提出问题：Despite the intertwined nature of development and regeneration, upstream cues and signaling mechanisms that commonly activate organogenesis are largely unknown. 

主要发现：Here, we demonstrate that next to being activators of regeneration, ETHYLENE RESPONSE FACTOR 114 (ERF114) and ERF115 govern developmental growth in the absence of wounding or injury. 

结果1-ERF114/115功能：Increased ERF114 and ERF115 activity enhances auxin sensitivity, which is correlated with enhanced xylem maturation and lateral root formation, whereas their knockout results in a decrease in lateral roots.  

结果2-ERF114/115上游促进信号：Moreover, we provide evidence that mechanical cues contribute to ERF114 and ERF115 expression in correlation with BZR1-mediated brassinosteroid signaling under both regenerative and developmental conditions. 

结果3-ERF114/115上游抑制信号：Antagonistically, cell wall integrity surveillance via mechanosensory FERONIA signaling suppresses their expression under both conditions. 

结论：Our data suggest a molecular framework in which cell wall signals and mechanical strains regulate organ development and regenerative responses via ERF114 and ERF115 mediated auxin signaling. 

植物表现出无与伦比的再生能力，使得其能够在遭受伤害、草食动物啃噬以及极端天气条件等严酷的胁迫环境下生存下来。植物的再生能力并不仅局限于受损组织或者器官的再生，而是可以从头再生出完整的植株。尽管发育和再生相互交织，但是激活器官再生的上游信号转导机制在很大程度上还是未知的。本文中，作者发现ERF114和ERF115基因作为再生的激活因子，能够在缺乏受损时赋予发育生长。ERF114和ERF115基因表达的提升能够增强生长素敏感性，与木质部成熟和侧根的形成相关，而这两个基因的敲除则会导致侧根数量的减少。此外，作者发现无论是在发育，还是在再生进程中，机械信号有助于促进ERF114和ERF115基因的表达，并与BZR1介导的油菜素内酯信号转导相关。与此同时，通过机械感FERONIA信号转导介导的细胞壁完整性监测能够抑制发育和再生进程中的ERF114和ERF115基因表达。本文的数据显示，细胞壁信号和机械应力通过ERF114/115介导的生长素信号转导，调控器官发育和再生响应。