Willsey et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell 2013, 155:997-1007. 基因组、表观基因组、转录组、蛋白质组、代谢组等组学数据是对复杂疾病不同层次的采样,如何有效的进行数据整合分析,进而得到有生物医学意义的发现是当前 ...
Dana Pe'er and Nir Hacohen. Principles and strategies for developing network models in cancer. Cell 2011, 144: 864-872. 准则1:分子间相互影响产生数据中的统计相关性(Molecular influences generate statistical relations in data) 准则2:网络不是一成不变的:上下文相关与动态性(Networks are not ...
Mitra et al. Integrative approaches for finding modular structure in biological networks. Nat Rev Genet 2013, 14:719-732. http://www.nature.com/nrg/journal/v14/n10/abs/nrg3552.html Abstract: A central goal of systems biology is to elucidate the structural and functional architecture of the cell. T ...