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知识发现系统和信息平台也是重要的科研信息获取途径和方法。
我的系列博文供大家参考。
信息检索系列博文 http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115380&view=me&from=space
信息分析系列博文 http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=114625&view=me&from=space
知识发现系列博文 http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space
信息检索、数据分析、知识发现都是科研人员的必备技能,一旦掌握,事半功倍。
许培扬 知识发现系列博文 http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&classid=115378&view=me&from=space
科学研究与知识发现 http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=327994
一项前沿性研究发现,如果某些基因被“删除”,人类寿命可以延长多达60%。科学家发现,如果对200多个基因进行“微调”,让它们变得不活跃,那么就可以让人类寿命延长几十年。
据英国《每日快报》网站10月12日报道,这项研究发现,在某些有机体身上,这一做法可以让寿命延长多达60%。这会让英国的人均寿命从81岁增加到一百多岁。
http://news.sina.com.cn/w/sy/2015-10-14/doc-ifxirmpz8317354.shtml
A-query: Gene and aging
C-query: human life-span
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 951 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 30306 and can be accessed from the start page after you leave this session. There are 1618 terms on the current B-list (601 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.
To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi
发现衰老与寿命的相关基因
job id # 30306 started Tue Oct 13 17:00:09 2015
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Gene and aging Tue Oct 13 17:00:17 2015
A query = Gene and aging started Tue Oct 13 17:00:18 2015
A query resulted in 36429 titles
C_query_raw: human life-span Tue Oct 13 17:01:59 2015
C: human life-span 11120
A: Gene and aging 36429
AC: ( Gene and aging ) AND ( human life-span ) 951
C_query_raw: human life-span Tue Oct 13 17:02:03 2015
C: human life-span 11120
A: Gene and aging 36429
AC: ( Gene and aging ) AND ( human life-span ) 951
C query = human life-span started Tue Oct 13 17:02:03 2015
C query resulted in 11120 titles
A AND C query resulted in 951 titles
22152 B-terms ready on Tue Oct 13 17:02:34 2015
Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
1618 B-terms left after filter executed Tue Oct 13 17:05:49 2015
B-list on Tue Oct 13 17:06:52 2015
1 adiponectin
2 brca1
3 toll receptor
4 jnk
5 wnt
6 mecp2
7 akt
8 vegf
9 ku70
10 mtor
11 huntingtin
12 frataxin
13 daf-16
14 sirtuin
15 caspase-3
16 microsatellite
17 serotonin transporter gene
18 p27kip1
19 signal regulated kinase
20 p66shc
21 helix loop helix
22 sirt3
23 caspase
24 sir2
25 cd28
26 cyclin dependent kinase
27 nestin
28 dystrophin
29 cdk2
30 mdx
31 rankl
32 pi3k
33 sp1
34 tdp-43
35 sirt1
36 cyclin e
37 htert gene
38 pten
39 jak stat
40 ucp2
41 sod1
42 prohibitin
43 mdm2
44 e2f1
45 cacna1a
46 grp78
47 anti mullerian hormone
48 parkin
49 leptin
50 k ras
51 map kinase
52 p53 tumor suppressor
53 mcl-1
54 gata-4
55 bdnf
56 microrna
57 p53 gene
58 id1
59 transporter gene
60 ts65dn
61 foxo
62 uncoupling protein
63 cip1
64 cd38
65 stat3
66 fat mass
67 prnp
68 swi
69 e polymorphism
70 brca2
71 swi snf
72 telomerase reverse transcriptase
73 klotho
74 cdna
75 cyclin d1
76 globin gene
77 adenovirus mediated gene
78 lrrk2
79 ampk
80 sgs1
81 heat shock factor
82 p16ink4a
83 lkb1
84 shc
85 bmi-1
86 bax
87 nanog
88 nod scid
89 matrix metalloproteinase
90 foxp3
91 foxo3a
92 serial analysis gene
93 peroxiredoxin
94 prion protein
95 caspase-8
96 lpr gene
97 waf1
98 apoe
99 c myc
100 mthfr
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=30306
研究课题实例
请见 AB文献与BC文献
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http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi
分子生物学数据库 Molecular Biology Databases
Symbol
Name
ID
Chr11:101488764-101551955bp, - strand From VEGA annotation of GRCm38 <!-- handle end 63192 bp ± kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer
|
|
HCOP human homology predictions:BRCA1
Protein SuperFamily: transcriptional regulator, BRCA1 type
Gene Tree: Brca1
Homozygous null mutants are embryonic lethal with abnormalities including growth retardation, neural tube defects, and mesoderm abnormalities; conditional mutations cause genetic instability and enhanced tumor formation; mutants with truncated BRCA1 protein survive, have a kinky tail, pigmentation anomalies, male infertility and increased tumor incidence.
Process | cell cycle, cellular response to DNA damage stimulus, ... |
Component | BRCA1-A complex, BRCA1-BARD1 complex, ... |
Function | chromatin binding, coenzyme F420-0 gamma-glutamyl ligase activity, ... |
VEGA Gene Model | OTTMUSG00000002870 (Evidence) |
Ensembl Gene Model | ENSMUSG00000017146 (Evidence) |
Entrez Gene | 12189 (Evidence) |
UniGene | 244975 |
DFCI | TC1577432, TC1625383, TC1693006 |
DoTS | DT.101407283, DT.529940, DT.97414487 |
NIA Mouse Gene Index | U033456 |
EC | 6.3.2.- |
Consensus CDS Project | CCDS25474.1 |
International Mouse Phenotyping Consortium Status | Brca1 |
Representative Sequences | Length | Strain/Species | Flank | |||
| genomic | OTTMUSG00000002870 | VEGA Gene Model | MGI Sequence Detail | 63192 | C57BL/6J | ± kb |
| transcript | OTTMUST00000005869 | VEGA | MGI Sequence Detail | 6572 | Not Applicable | |
| polypeptide | OTTMUSP00000002773 | VEGA | MGI Sequence Detail | 1812 | Not Applicable | |
For the selected sequences download in FASTA format forward to MouseBLASTAll sequences(61)RefSeq(7)UniProt(8)
Resource | ID | Description |
InterPro | IPR031099 | BRCA1-associated |
InterPro | IPR025994 | BRCA1, serine-rich domain |
InterPro | IPR001357 | BRCT domain |
InterPro | IPR011364 | Breast cancer type 1 susceptibility protein (BRCA1) |
InterPro | IPR018957 | Zinc finger, C3HC4 RING-type |
InterPro | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
InterPro | IPR001841 | Zinc finger, RING-type |
InterPro | IPR017907 | Zinc finger, RING-type, conserved site |
Contributing Projects: |
http://www.informatics.jax.org/marker/key/24690
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