The following is a summary of some very heated debate in China on the Han NgAgo paper.
1. Fang's rash accusation of fraud was a mere result of his misunderstandings of the Han paper and molecular biology in general. Even one of Fang's ardent supporters pointed out to him that he misinterpreted the electrophoresis bands presented in the paper. Fang further mistook distances between target sites for DNA segment size deltas.
2. Another named person, who was Fang's main source, has been discredited in a direct online debate, for failing to consider NgAgo's effect of removing 1 to 20 nts at the target site.
3. As stated in Han's paper, the guide can be loaded only when the NgAgo protein is in the process of expression. Dr. Burgio admitted that he did not follow a starred procedure in Han's published protocol.
Thus far, the accusations of fraud have been shown to be unfounded. A single successful replication is sufficient to qualitatively vindicate Han's result. Hopefully, the suspicion and ridicule will trigger more curiosity and research to bring about more definitive answers, instead of misguided abandonment of a potentially potent tool for gene editing.