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科技英语写作基础(系列):阅读摘要Dietary restriction mechanism

已有 869 次阅读 2020-12-7 07:46 |个人分类:Scientific Writing|系统分类:论文交流

科技英语写作基础(系列):阅读摘要Dietary restriction mechanism

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Yellow means "questionable."


Blue is for discussion.


Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids


Dietary restriction (DR) promotes healthy aging in diverse species. 


Essential amino acids play a key role, but the molecular mechanisms are unknown. 


The evolutionarily conserved Sestrin protein, an inhibitor of activity of the target of rapamycin complex 1 (TORC1), has recently been discovered as a sensor of amino acids in vitro. 


Here, we show that Sestrin null mutant flies have a blunted response of lifespan to DR. 


A mutant Sestrin fly line, with blocked amino acid binding and TORC1 activation, showed delayed development, reduced fecundity, extended lifespan and protection against lifespan-shortening, high-protein diets. 


Sestrin mediated reduced intestinal stem cell activity and gut cell turnover from DR, and stem cell proliferation in response to dietary amino acids, by regulating the TOR pathway and autophagy. 

评论:TOR needs to be defined first.


Sestrin expression in intestinal stem cells was sufficient to maintain gut homeostasis and extend lifespan. 


Sestrin is thus a molecular link between dietary amino acids, stem cell function and longevity.

评论:between a and b. Has English advanced so much now that one can use “between a, b and c”?

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