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喜欢十一长假,因为我又可以静静地坐在办公室中静静地思考些问题。也有机会打理下我的“科学网”博客。今天开始我决定把我的博客名称从“钛镁的生物材料世界”改成“革命性的生物医用金属材料”!其实这词不是我造的,如果你到http://erc.ncat.edu/ 看看,就会知道在美国有个叫“Revolutionizing Metallic Biomaterials”的NSF的工程研究中心(一个主要的方向就是做可降解镁合金),我挺喜欢“Revolutionizing”这个英文表述。但实事求是地讲,目前离“革命”尚早,还没有任何新产品面世。
概括地说从2004年以来,我的实验室(http://lbmd.coe.pku.edu.cn)除了坚持做传统的医用钛合金(低模量生物相容的钛合金、无镍生物医用钛基形状记忆合金)及其表面改性方向外,逐渐做了生物医用金属材料的降解化(NSFC面上)、非晶化(NSFC面上)和纳米化(973参与)三个方面的“革命性”探索研究(重点是发展三维块体材料及其表面改性技术), 只能说我“胡做”一下,不对地方还请大家多多指正(我已经被我很敬重的一位学者批评过了(他认为目前生物材料已经过了随便拿个材料就试的阶段),很感谢,至今都觉得他说的有道理,也一直在努力做些有意义的原创工作)。
一、可降解金属;截至目前,我们在开展医用镁基合金和铁基合金研究(抱歉,铁已经做了几年还没有文章刊出来)。在医用镁合金方面我们发展了生命元素组成的Mg-Ca合金体系,利用表面改性技术来调控其降解速度,评价了各种合金化元素的细胞毒性,并开展了复合材料、多孔材料等新颖结构的医用镁合金研究,还在研究医用镁合金的腐蚀疲劳行为。在铁基合金方面,我们正试图用一些办法来提高其腐蚀速度。
(1)综述文章
郑玉峰,刘彬,顾雪楠,可生物降解医用金属材料的研究进展,材料导报,第23卷,第1期,1-7页,(2009)
Xue-Nan GU, Yu-Feng ZHENG, A review on magnesium alloys as biodegradable materials, Front. Mater. Sci. China 2010, 4(2): 111–115
(2)纯镁体系(Mg/HA复合材料、藕状多孔)
Xuenan Gu, Yufeng Zheng, Limin Dong, Yulin Xi and Donglang Chai, Microstructure, mechanical property, bio-corrosion and cytotoxicity evaluations of Mg/HA composites, Materials Science and Engineering C, 30 (2010), pp. 827-832
X.N. Gu, W.R. Zhou, Y.F. Zheng, Y. Liu and Y.X. Li, Degradation and cytotoxicity of lotus-type porous pure magnesium as potential tissue engineering scaffold material, Materials Letters, 64 (2010) 1871-1874
(3)医用Mg-Ca合金体系(二元合金、Mg/Ca复合材料、甩带)及其表面改性(壳聚糖、碱热、微弧氧化)
Zijian Li, Xuenan Gu, Shiqing Lou and Yufeng Zheng, The development of binary Mg-Ca alloys for use as biodegradable materials within bone. Biomaterials, Vol.29, pp.1329-1344 (2008)
X.N. Gu, Y.F. Zheng, Q.X. Lan, Y. Cheng, Z.X. Zhang, T.F. Xi and D.Y. Zhang, Surface Modification of Mg-1Ca alloy to slow down its biocorrosion by Chitosan, Biomedical Materials, 4 (2009) 044109
X.N. Gu, W. Zheng, Y. Cheng and Y.F. Zheng, Study on alkaline-heat treated Mg-Ca alloy for the control of the biocorrosion rate, Acta Biomaterialia, Volume 5, Issue 7, Pages 2790-2799, (2009)
Y.F. Zheng and X.N. Gu, Y.L.Xi and D.L.Chai, In vitro biocorrosion and cytotoxicity of Mg/Ca composite, Acta Biomaterialia, Volume 6, Issue 5, Pages 1783-1791 (2010)
X.N. Gu, X.L. Li, W.R. Zhou, Y. Cheng and Y.F. Zheng, Microstructure, biocorrosion and cytotoxicity evaluations of rapid solidified Mg-3Ca alloy ribbion as biodegradable material, Biomedical Materials, 5 (2010) 035013
(4)医用Mg-1X(X= Al, Ag, In, Mn, Si, Sn, Y, Zn and Zr)合金元素模型的体外评价
Xuenan Gu, Yufeng Zheng, Yan Cheng, Shengping Zhong and Tingfei Xi, Biomaterials, Vol.30, pp.484-498 (2009)
(5)医用Mg合金的体外腐蚀评价方法
X.N. Gu, Y.F. Zheng and L.J. Chen, Influence of artificial biological fluid composition on the biocorrosion behavior of potential orthopedic Mg-Ca, AZ31 and AZ91 alloys, Biomedical Materials, 4 (2009) 065011
(6)医用Mg合金的体液腐蚀疲劳行为
X.N. Gu, W.R. Zhou, Y.F. Zheng, Y.Chen, S.P. Zhong, T.F. Xi and L.J. Chen, Corrosion fatigue behavior of two typical biomedical Mg alloys-AZ91D and WE43 in simulated body fluid, Acta Biomaterialia 6 (2010) 4605-4613
二、大块非晶合金作为医用金属材料的探索性研究;截至目前,我们已经开展了Mg基、Fe基、Ca基、Ti基、Zr基非晶体系的生物相容性评价。
(1)综述文章
郑玉峰, 李华芳,王彦波,顾雪楠,大块非晶合金作为生物医用材料的探索性研究进展,材料导报,第24卷,第5期,1-6页,(2010)
(2)Fe基BMG
Y. B. Wang, H.F. Li, Y. Cheng, S.C. Wei and Y.F. Zheng, Corrosion performance of a Nickel-free Fe-based bulk metallic glass in simulated body fluids, Electrochemistry Communications, 11 (2009) 2187-2190
(3)Zr基BMG
Y.B. Wang, H.F. Li, Y.F. Zheng, S.C. Wei and M. Li, Correlation between corrosion performance and surface wettability in ZrTiCuNiBe bulk metallic glasses, Applied Physics Letters, 96, 251909 (2010)
Y.B. Wang, Y.F. Zheng, S. C. Wei and M. Li, In vitro study on Zr-based bulk metallic glass as potential biomaterial, Journal of Biomedical Materials Research B, online (2010)
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31725/full
(4)Mg基BMG
X.N. Gu, Y.F. Zheng, S.P. Zhong, T.F. Xi, J.Q. Wang and W.H. Wang, Biocorrosion and Cytotoxicity evalution of Mg-Zn-Ca bulk metallic glass, Biomaterials,