博文
- Molecular fluorescent probes for monitoring pH changes
- The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-media ...
- 基于羟胺氧化的PET Fe3+探针
- 设计了一种增强型荧光探针（ BOD-NHOH ），通过基于羟胺氧化的光诱导电子转移（ photoinduced electron transfer, PET ），可与 Fe 3+ 选择性发生氧化还原反应，抗干扰能力很强。该探针可成功应用于复杂细胞介质的实时荧光成像。 Rui Wang, Fabiao Yu,Ping Liu, Lingxin Chen * , A Turn-On Fluorescen ...
- 气体信号分子硫化氢的抗氧化应激功能
- 热度 1
- 硫化氢（ H 2 S ），这个具有令人厌恶气味的气体，被确定为第三个具有生物活性的气体信号分子，参与调节血管张力，心肌收缩，神经传导，胰岛素分泌等生理过程。本工作报道了一种能选择性响应细胞内硫化氢的比色和比率荧光探针 。此探针可以方便地用于评估细胞内硫化氢水平，实现了对细胞内硫化氢的激光共聚焦比率成像 ...
- 双氧水/谷胱甘肽连续检测
- 热度 1
- 双氧水（ H 2 O 2 ）可作为细胞正常生长和增殖的第二信使。但是，如果超过生理致毒水平的阈值，就会导致因 H 2 O 2 和抗氧化防御系统之间的不平衡而引起的氧化应激。本工作描述了一个具有“开 - 关 - 开”特征的荧光探针的设计、合成、光谱性质及其生物应用。该探针可以简单直接地检测活细胞和组织内 H 2 O 2 ...
- 次溴酸/抗坏血酸可逆检测
- 次溴酸（ HBrO ）被认为是中性粒细胞主机防御系统的重要组成部分，但是过度产生或者在错误的地方生成可导致宿主的组织损伤，进而引发许多的疾病，包括关节炎、癌症、哮喘等。本文报道了两种新型可逆次溴酸荧光探针的合成，光谱性质及其生物应用。我们将这两种探针用于模拟生理条件下水溶液中 HBrO 的检测和活细胞内 ...
- 过氧化亚硝酰/谷胱甘肽的氧化循环检测
- 过氧化亚硝酰（ ONOO - ）和谷胱甘肽 (GSH) 之间的氧化还原平衡与一些生理和病理过程有着密切的关系，针对这个问题，报道了两种用于监测细胞和体内 ONOO - /GSH 水平变化情况的近红外荧光探针。该类型探针集成了硒 / 碲酶模拟物作为受体用以可逆地检测 ONOO - /GSH 水平的变化。该探针被成功地应用到细胞和动 ...
- Near-infrared Fluorescent Probe for Hydrogen Polysulfides
- Near-infrared Fluorescent Probe for ImagingMitochondrial Hydrogen Polysulfides in Living Cells and in vivo Hydrogen polysulfides (H 2 S n , n 1), derived from hydrogen sulfide (H 2 S), have attractedincreasing attention in biochemical research, which may perform as the actualsi ...
- Fluorescent probes for hydrogen sulfide detection
- 热度 1
- Fluorescent probes for hydrogen sulfide detection and bioimaging In comparison with other biological detection technologies, fluorescence bioimaging technology has become a powerful supporting tool for intracellular detection, and can provide attractive facilities for investigating physi ...
- Visualization of nitroxyl (HNO) in vivo via a lysosome-targe
- Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe We have presented a near-infraredfluorescent probe Lyso-JN for the detection ofnitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a ...
- 发表论文
- 1 、 Fabiao Yu , Xiaoyue Han and Lingxin Chen, Fluorescent probesfor hydrogen sulfide detection and bioimaging. Chem. Comm. , 2014 , 50, 12234. 2 、 Xiaotong Jing,‡ FabiaoYu ‡ and Lingxin Chen, Visualization of nitroxyl (HNO) in vivo via alysosome-targetable near-infrar ...
