过氧化亚硝酰（ONOO^-）和谷胱甘肽(GSH)之间的氧化还原平衡与一些生理和病理过程有着密切的关系，针对这个问题，报道了两种用于监测细胞和体内ONOO^-/GSH水平变化情况的近红外荧光探针。该类型探针集成了硒/碲酶模拟物作为受体用以可逆地检测ONOO^-/GSH水平的变化。该探针被成功地应用到细胞和动物体内的ONOO^-爆发和抗氧化剂GSH修复间期的氧化还原循环变化的可视化检测。

Fabiao Yu, Peng Li, Bingshuai Wang, and Keli Han*,Reversible near-infrared fluorescent probe introducing tellurium to mimeticglutathione peroxidase for monitoring the redox cycles between peroxynitriteand glutathione in vivo.J. Am. Chem.Soc.135, 7674-7680, 2013.

Fabiao Yu, Peng Li, Guangyue Li, Guangjiu Zhao,Tianshu Chu, and Keli Han*, A near-IR reversible fluorescent probe modulated byselenium for monitoring peroxynitrite and imaging in living cells. J. Am. Chem. Soc. 133,11030-11033, 2011.