近2-3年来，我们课题组（包括合作者）一部分工作集中在研究失神癫痫的基底节调控机制，目前在局部神经回路模型方面已经有了一定的积累。其中核心的两个工作总结如下：1）我们发现正常状态提升和降低SNr的均可能有效的抑制2-4 HzSWDs的产生，因此首次提出基底节可能对失神癫痫具有双向调控作用；2）我们发现近期实验证实的GPe到皮层的抑制性投射通路可能对失神癫痫具有重要的调控作用。此外，我们也在试图将这些回路的调控机制在模型鼠上做进一步验证。感兴趣的读者可以参见下列论文：

Mingming Chen^#, Daqing Guo^{* #}, Min Li, Tao Ma, Shengdun Wu, Jingling Ma, Yan Cui, Yang Xia, Peng Xu, and Dezhong Yao^* 

Critical Roles of the Direct GABAergic Pallido-cortical Pathway in Controlling Absence Seizures,

PLoS Comput Biol, 11(10): e1004539, 2015.

Mingming Chen^#, Daqing Guo^*#, Tiebin Wang, Jing Wei, Xia Yang, Peng Xu, Cheng Luo, Pedro A. Valdes-Sosa, Dezhong Yao^* 

Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence, 

PLoS Comput Biol, vol. 10, p.e1003495, 2014.

Bing Hu, Daqing Guo, Qingyun Wang*,

Control of Absence Seizures Induced by the Pathways Connected to SRN in Corticothalamic System,

Cognitive Neurodynamics,9 (3), 279-289, 2015.

Mingming Chen, Min Li, Tao Ma, Daqing Guo*,Yang Xia, Dezhong Yao*，

New Insights for the Basal Ganglia in Controlling Absence Seizures,

Accepted by the 7th International Workshop on Seizure prediction, 2015, Melbourne, Australia. (travel award: A$1,500)

Mingming Chen, Cheng Luo, Yang Xia, Daqing Guo*,and Dezhong Yao.

Absence epilepsy regulated by basal ganglia: A modeling study,

The 30th International Epilepsy Congress, Special Issue on Epilepsia, 54(s3), P147, 2013.