Wiley | 2008-08-18 | ISBN: 047010211X | 902 pages

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals. Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels.   

Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition.   

Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style.   

Additional features of this new edition include:   

- New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics   

- Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters   

- Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity   

Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects   

Publisher: John Wiley   

 

 

Wiley-Interscience | 2008-04-04 | ISBN: 0470868937 | 698 pages

This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures.  

With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps. In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections:

-Principles in Toxicology  

-Organ Toxicology  

-Methods in Toxicology  

-Risk Assessment  

-Risk Management   

-Toxicity of Chemicals  

Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.  

Publisher: John Wiley  

For more information please click on:  

http://www.researchandmarkets.com/product/be0f2f/toxicology_and_risk_assessment_a_comprehensi  

Title Index:  

- Contents  

- Introduction to the Discipline of Toxicology  

- Toxicokinetics  

- Phase I metabolism  

- Phase II metabolism  

- Toxicogenetics  

- Cytotoxicity  

- Receptor-Mediated Mechanisms  

- Mixtures and Combinations of Chemicals  

- Chemical Carcinogenesis: Genotoxic and non-genotoxic mechanisms  

- Reproductive Toxicology  

- Ecotoxicology: not just wildlife technology  

- Gastrointestinal Tract  

- The Liver  

- Respiratory System  

- The Nervous System  

- Behavioral Neurotoxicology  

- Skin  

- Kidney and urinary tract  

- Toxicology of the blood and bone marrow  

- Immunotoxicology  

- The Eye  

- The Cardiovascular System  

- OECD test guidelines for toxicity tests in vivo  

- Mutagenicity tests in vivo  

- In Vitro Tests for Genotoxicity  

- Strategies for the evaluation of genotoxicity  

- Biomonitoring  

- Epidemiology  

- Omics in toxicology  

- Introduction to the statistical analysis of experimental data  

- Mathematical models for risk extrapolation.  

- Regulations regarding chemicals and radionuclides in the environment, workplace, consumer products, foods and pharmaceuticals  

- Persistent Polyhalogenated Aromatic Hydrocarbons  

- Metals  

- Toxicology of Fibers and Particles  

- Xenoestrogens and Xenoantiandrogens  

- Toxicology of Solvents  

- Noxious Gases  

- Animal and Plant Toxins  

- Index  

 

偷偷说一声，这两本书在网上都有电子版。