SR-717(AbMole,M9923)是一种非核苷酸类小分子STING激动剂,它作为环鸟苷酸-腺苷酸(cGAMP)的模拟物,诱导STING蛋白形成“闭合”构象,从而激活下游信号通路 。在分子水平上,SR-717( CAS No.:2375421-09-1)显著增强了STING通路的磷酸化,包括TANK结合激酶1(TBK1)、干扰素调节因子3(IRF3)和STAT3的磷酸化,并促 ...
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