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生命 = f(环境, t)：从传统智慧到新生物学范式

许越^1,2,3,4

1.    中关村旭月非损伤微测技术产业联盟，中国，北京 100080

2.    NMT国际联盟，南迪尔菲尔德 ，美国马萨诸塞州01373

3.    旭月（北京）科技有限公司，中国，北京 100080

4.    美国扬格公司，南迪尔菲尔德 ，美国马萨诸塞州01373

通讯作者： 许越, jeff@xuyue.net

摘要 本文提出了一个通过公式 生命 = f(环境, t) 来理解生命的综合性框架，认为生命系统的状态是其环境和时间的函数。它将这一概念的哲学起源追溯到中国古代“天人合一”的智慧，并将其系统地发展成一个现代科学范式。本文主张生命科学应从静态的“解码”生物组件，转向基于实时交互的动态“调控”。该框架的核心是 离子分子组学(imOmics)，它被提议作为量化函数关系‘f’的科学语言，其焦点在于生命与环境界面上的离子和分子流。实现离子分子组学的使能技术是 非损伤微测技术 (NMT)，它允许对这些动态交换进行活体、原位、实时的测量。宏大的 全球离子分子组计划 (GiP) 被概述为一项大规模倡议，旨在全球范围内验证和应用该框架，涵盖智慧农业、精准医学和环境监测等多个领域。最后，文章引入了 新生物学范式——DNA → RNA → 蛋白质 → 离子分子组 → 表型，作为中心法则的关键延伸，强调了实时离子和分子交换（离子分子组）在连接遗传信息与宏观表型中的作用，从而架起了内部遗传指令与外部环境交互之间的桥梁。

关键词： 生命 = f(环境, t)，离子分子组学 (imOmics)，非损伤微测技术 (NMT)，全球离子分子组计划 (GiP)，新生物学范式（DNA → RNA → 蛋白质 → 离子分子组 → 表型）

doi: 10.5281/zenodo.17809686

Life = f(Environment, t) From Traditional Wisdom to a New Biology Dogma

Yue Jeff Xu^1,2,3,4

1. Zhongguancun Xuyue NMT Industrial Alliance, Beijing 100080, China

2. NMT International Alliance, South Deerfield, Massachusetts 01373, USA

3. Xuyue (Beijing) Sci. & Tech. Co., Ltd., Beijing 100080, China

4. YoungerUSA LLC, South Deerfield, Massachusetts 01373, USA 

Corresponding author:

Yue Jeff Xu, jeffxu@youngerusa.com

Abstract

This article presents a comprehensive framework for understanding life through the formula Life = f(Environment, t), positing that the state of a living system is a function of its environment and time. It traces the philosophical origins of this concept to the ancient Chinese wisdom of "Harmony between Heaven and Humanity" and systematically develops it into a modern scientific paradigm. The paper argues for a shift in life sciences from static "decoding" of biological components to dynamic "regulation" based on real-time interactions. Central to this framework is Ionic & Molecular Omics (imOmics), proposed as the scientific language to quantify the functional relationship 'f' by focusing on the fluxes of ions and molecules at the interface between life and its environment. The enabling technology for imOmics is Non-invasive Micro-test Technology (NMT), which allows for in vivo, in situ, and real-time measurement of these dynamic exchanges. The ambitious Global imOme Project (GiP) is outlined as a large-scale initiative to validate and apply this framework globally across various fields, including smart agriculture, precision medicine, and environmental monitoring. Finally, the article introduces a New Biology Dogma—DNA → RNA → Protein → imOme → Phenotype—as a crucial extension of the Central Dogma, emphasizing the role of real-time ion and molecule exchanges (the imOme) in connecting genetic information to macroscopic phenotypes, thereby bridging internal genetic instructions with external environmental interactions.

Key Words:  

Life = f(Environment, t), Ionic & Molecular Omics (imOmics), Non-invasive Micro-test Technology (NMT), Global imOme Project (GiP), New Biology Dogma（DNA → RNA → Protein → imOme → Phenotype）

doi : 10.5281/zenodo.17464317