JCI——ArcN NPY—PVN/DMH通路介导了肥胖引起的交感神经系统兴奋增强

Abstract

1.Selective activation and inhibition of ArcN NPY/AgRP neurons decreases and increases SNA, respectively.

2.Neurons in the PVN, DMH, and LH that project to the RVLM appear to receive inputs from ArcN NPY/AgRP neurons.

3.Bilateral nanoinjections of NPY or BIBO3304 into the PVN and DMH of WT mice decrease and increase SSNA, HR, and MAP, respectively

4. Bilateral nanoinjection of BIBO3304 into the DMH, but not the PVN, reverses the effects of select activation of ArcN NPY/AgRP neurons

5.Bilateral nanoinjection of CNO into the PVN or DMH of ArcN hM3Dq mice decreases SSNA, HR, and MAP, and these responses are reversed by subsequent PVN or DMH injections of BIBO3304.

6.Inhibition of the DMH reverses the increases in SSNA, HR, and MAP induced by bilateral nanoinjections of IBO3304 into the PVN.

7.Model illustrating proposed neurocircuitry by which ArcN NPY neurons inhibit SNA

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