▲ Vol 37 Issue 32 | August 14, 2025

Natural van der Waals Canalization Lens for Non-Destructive Nanoelectronic Circuit Imaging and Inspection

Qingdong Ou, Shuwen Xue, Weiliang Ma, Jiong Yang, Guangyuan Si, Lu Liu, Gang Zhong, Jingying Liu, Zongyuan Xie, Ying Xiao, Tian Sun, Ding Yuan, Kourosh Kalantar-Zadeh, Peining Li, Zhigao Dai, Huanyang Chen, Qiaoliang Bao

Super-Resolution Imaging

In article number 2504526, Qingdong Ou, Zhigao Dai, Huanyang Chen, Qiaoliang Bao, and colleagues demonstrate that van der Waals canalization lenses enable multi-directional super-resolution imaging of buried electronic circuits with sub-15 nm resolution.

https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.70083

▲ Vol 28 Issue 08 | August 15, 2025

TFAP2A enhances tumor stemness and promotes metastasis in pancreatic ductal adenocarcinoma

Jiaxin Luo, Zezhi Ding, Dongjie Chen, Yongsheng Jiang, Yizhi Cao, Minmin Shi, Xiaomei Tang,  Jia Liu, Meilin Xue,  Zehui Zhang, Kexian Li, Yu Bao, Fangfang Ma, Ting Wang, Lingxi Jiang

Metastasis is the leading cause of death for nearly 90% of patients with cancer. In the digestive system, malignancies preferentially metastasize to the liver, which occurs in 76–80% of patients with pancreatic ductal adenocarcinoma (PDAC). Given the shared endoderm origin of embryonic pancreas and liver, this study investigated whether genes highly expressed in liver progenitors drive PDAC cells metastasize to the liver. Using an in vitro liver differentiation model, genes highly expressed in liver progenitors were identified. Among them, TFAP2A was highly expressed in PDAC and closely related to PDAC liver metastasis. Cancer associated fibroblasts (CAFs) upregulated TFAP2A expression by bone morphogenetic protein 4 (BMP4). Functional experiments demonstrated that TFAP2A overexpression promoted PDAC cell stemness and liver metastasis in vitro and in vivo. Mechanistically, TFAP2A could promote epithelial mesenchymal transition (EMT) and recruit macrophage by upregulating MYC, facilitating PDAC cell intravasation. Collectively, these findings unveil molecular mechanisms for PDAC liver metastasis and potential therapeutic targets.

https://www.cell.com/iscience/fulltext/S2589-0042(25)01321-5

▲ Vol 12 Issue 30 | August 14, 2025

Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase-Mimicking and Sonodynamic Activities for Cancer Combination Treatment

Meng Yang, Yang Meng, Junling Li, Liya Bai, Yuanyuan Cheng, Yuanyuan Liu, Mingxin Cao, Xiaoying Yang, Yinsong Wang, Yang Liu

Bacterial Cell Wall-Mediated Combination Therapy

In article number 2505310 by Xiaoying Yang, Yinsong Wang, Yang Liu, and co-workers, DOX-loaded bacterial cell walls (DOX@CWV) with intrinsic peroxidase-mimicking and sonodynamic (SDT) activity are reported. DOX@CWV integrates SDT, chemotherapy, and bacterial immunotherapy to effectively inhibit tumor growth and metastasis, underscoring its potential for advanced cancer treatment.

https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.71158

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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。

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