2025诺贝尔生理学或医学奖得主  弗雷德·拉姆斯德尔（Fred Ramsdell）的学术成果

2025 年 10 月 6 日北京时间 17 时 30 分许，2 位美国科学家玛丽·E·布伦科（Mary E. Brunkow）、弗雷德·拉姆斯德尔（Fred Ramsdell）和 1 位日本科学家坂口志文（Shimon Sakaguchi）因在外周免疫耐受方面的发现，获得 2025 年诺贝尔生理学或医学奖。

https://mp.weixin.qq.com/s/mRYjo36DATqoIiHnn2OSKA

学术论文检索结果

https://pubmed.ncbi.nlm.nih.gov/?term=%28Ramsdell++F%29+AND+%28Ramsdell++F%29&sort=

学术论文分析结果

http://www.pubmedplus.cn/P/SearchQuickResult?wd=ce3bee9e-9214-4740-8465-bf79fb1c9118

https://pubmed.ncbi.nlm.nih.gov/37153574/

Review Front Immunol . 2023 Apr 19:14:1166135. doi: 10.3389/fimmu.2023.1166135. eCollection 2023. Opportunities for Treg cell therapy for the treatment of human disease Jeffrey A Bluestone 1, Brent S McKenzie 1, Joshua Beilke 1, Fred Ramsdell 1 Affiliations expand PMID: 37153574 PMCID: PMC10154599 DOI: 10.3389/fimmu.2023.1166135 Abstract Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population can develop in the thymus and in the peripheral tissues of the immune system through the expression of an epigenetically stabilized transcription factor, FOXP3. Treg cells mediate their tolerogenic effects using multiple modes of action, including the production of inhibitory cytokines, cytokine starvation of T effector (e.g., IL-2), Teff suppression by metabolic disruption, and modulation of antigen-presenting cell maturation or function. These activities together result in the broad control of various immune cell subsets, leading to the suppression of cell activation/expansion and effector functions. Moreover, these cells can facilitate tissue repair to complement their suppressive effects. In recent years, there has been an effort to harness Treg cells as a new therapeutic approach to treat autoimmune and other immunological diseases and, importantly, to re-establish tolerance. Recent synthetic biological advances have enabled the cells to be genetically engineered to achieve tolerance and antigen-specific immune suppression by increasing their specific activity, stability, and efficacy. These cells are now being tested in clinical trials. In this review, we highlight both the advances and the challenges in this arena, focusing on the efforts to develop this new pillar of medicine to treat and cure a variety of diseases. Keywords: Foxp3; Treg; autoimmunity; immune regulation; immune tolerance. Copyright © 2023 Bluestone, McKenzie, Beilke and Ramsdell. PubMed Disclaimer